| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 25 | 25 | 12 | 5 | 2.68 | .237 | 0.91 | 5.6 | 2.6 | 7.3 | 178.0 | 111 | 56 | 53 | 18 | 51 | 145 | 0 | 0 | 0 | 0 | 18 | 4 | 0 | 3.61 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 25 | 25 | 12 | 10 | 3.83 | .282 | 1.18 | 8.1 | 2.5 | 6.8 | 181.0 | 163 | 78 | 77 | 17 | 50 | 137 | 6 | 0 | 0 | 1 | 16 | 0 | 4 | 3.54 |
| SP | Blue, V.Blue, Vida † # >> | 22 | 1971 | L | 79 | 24 | 24 | 15 | 4 | 2.89 | .267 | 1.08 | 7.1 | 2.6 | 6.8 | 193.1 | 153 | 63 | 62 | 12 | 56 | 145 | 9 | 0 | 0 | 2 | 17 | 2 | 4 | 3.21 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 23 | 23 | 15 | 5 | 2.85 | .284 | 1.17 | 7.1 | 3.5 | 6.8 | 157.2 | 123 | 52 | 50 | 15 | 61 | 119 | 1 | 0 | 0 | 0 | 19 | 4 | 0 | 3.97 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 36 | 0 | 4 | 1 | 3.25 | .260 | 1.06 | 6.5 | 3.0 | 7.8 | 36.0 | 26 | 13 | 13 | 2 | 12 | 31 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 14 | 0 | 0 | 4 | 7.36 | .313 | 1.27 | 6.5 | 4.9 | 9.8 | 11.0 | 8 | 9 | 9 | 3 | 6 | 12 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 6.27 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 9 | 0 | 0 | 0 | 1.42 | .296 | 1.26 | 12.0 | 0.0 | 6.0 | 6.1 | 8 | 1 | 1 | 0 | 0 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.67 |
| RP | Eichhorn, M.Eichhorn, Mark # >> | 26 | 1986 | R | 48 | 20 | 0 | 1 | 0 | 5.76 | .318 | 1.40 | 6.1 | 6.5 | 7.2 | 25.0 | 17 | 16 | 16 | 3 | 18 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.12 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 49 | 0 | 5 | 2 | 1.94 | .234 | 0.92 | 4.3 | 4.1 | 8.3 | 55.2 | 26 | 12 | 12 | 2 | 25 | 51 | 0 | 22 | 3 | 0 | 0 | 0 | 0 | 2.98 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 40 | 3 | 0 | 0 | 0 | 6.23 | .264 | 1.00 | 7.6 | 1.4 | 7.6 | 13.0 | 11 | 9 | 9 | 3 | 2 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.00 |