| SP | Glasnow, T.Glasnow, Tyler >> | 27 | 2021 | R | 100 | 8 | 8 | 4 | 3 | 1.98 | .287 | 1.19 | 8.0 | 2.8 | 10.7 | 54.2 | 48 | 12 | 12 | 5 | 17 | 64 | 1 | 0 | 0 | 1 | 5 | 1 | 10 | 2.83 |
| SP | Peralta, F.Peralta, Freddy >> | 25 | 2021 | R | 98 | 8 | 8 | 4 | 2 | 3.86 | .289 | 1.17 | 7.8 | 2.9 | 10.0 | 44.1 | 38 | 20 | 19 | 9 | 14 | 49 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.52 |
| SP | Alcantara, S.Alcantara, Sandy >> | 25 | 2021 | R | 83 | 8 | 8 | 3 | 5 | 5.29 | .321 | 1.40 | 9.2 | 3.5 | 8.1 | 49.1 | 50 | 33 | 29 | 8 | 19 | 44 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 4.55 |
| SP | DeSclafani, A.DeSclafani, Anthony >> | 31 | 2021 | R | 80 | 7 | 7 | 1 | 3 | 6.88 | .354 | 1.64 | 12.6 | 2.3 | 9.3 | 35.1 | 49 | 28 | 27 | 10 | 9 | 36 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 5.43 |
| SP | Ohtani, S.Ohtani, Shohei >> | 26 | 2021 | R | 91 | 7 | 7 | 2 | 2 | 3.35 | .328 | 1.44 | 8.3 | 4.7 | 11.5 | 40.1 | 37 | 17 | 15 | 7 | 21 | 51 | 0 | 0 | 0 | 0 | 3 | 1 | 4 | 4.38 |
| CL | Jansen, K.Jansen, Kenley >> | 33 | 2021 | R | 97 | 16 | 0 | 2 | 1 | 3.65 | .383 | 1.62 | 6.8 | 8.3 | 9.0 | 12.1 | 9 | 5 | 5 | 1 | 11 | 12 | 0 | 8 | 0 | 0 | 0 | 3 | 3 | 5.58 |
| SU | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 91 | 15 | 0 | 1 | 0 | 6.57 | .339 | 1.54 | 9.0 | 5.3 | 8.3 | 12.1 | 12 | 10 | 9 | 4 | 7 | 11 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 7.25 |
| RP | Boxberger, B.Boxberger, Brad >> | 33 | 2021 | R | 90 | 21 | 0 | 1 | 0 | 5.57 | .323 | 1.43 | 8.6 | 4.3 | 8.6 | 21.0 | 20 | 13 | 13 | 4 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Loaisiga, J.Loaisiga, Jonathan >> | 26 | 2021 | R | 79 | 20 | 0 | 0 | 1 | 8.49 | .320 | 1.37 | 10.6 | 2.0 | 7.4 | 23.1 | 27 | 22 | 22 | 7 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.09 |
| RP | Rogers, T.Rogers, Tyler >> | 30 | 2021 | R | 62 | 16 | 0 | 1 | 0 | 2.60 | .212 | 0.81 | 5.8 | 1.6 | 6.9 | 17.1 | 11 | 5 | 5 | 1 | 3 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.76 |
| SP | Civale, A.Civale, Aaron >> | 26 | 2021 | R | 75 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 31 | 2021 | R | 60 | 1 | 0 | 0 | 0 | 6.75 | .360 | 1.69 | 12.6 | 3.6 | 10.8 | 5.1 | 7 | 4 | 4 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.80 |
| SP | Greinke, Z.Greinke, Zack >> | 38 | 2021 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |