| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 96 | 8 | 8 | 3 | 4 | 2.78 | .270 | 1.05 | 6.9 | 2.6 | 7.4 | 55.0 | 42 | 17 | 17 | 9 | 16 | 45 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 4.53 |
| SP | Ohtani, S.Ohtani, Shohei >> | 26 | 2021 | R | 91 | 8 | 8 | 2 | 2 | 2.35 | .251 | 0.93 | 6.1 | 2.4 | 8.3 | 53.2 | 36 | 18 | 14 | 4 | 14 | 49 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 3.15 |
| SP | McKenzie, T.McKenzie, Triston >> | 23 | 2021 | R | 85 | 8 | 8 | 3 | 2 | 2.13 | .302 | 1.28 | 4.7 | 6.9 | 11.8 | 42.1 | 22 | 10 | 10 | 3 | 32 | 55 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.67 |
| SP | Gonsolin, T.Gonsolin, Tony >> | 27 | 2021 | R | 59 | 7 | 7 | 0 | 1 | 3.38 | .292 | 1.24 | 7.3 | 4.2 | 10.7 | 26.2 | 21 | 13 | 10 | 4 | 12 | 31 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 4.00 |
| RP | Doval, C.Doval, Camilo >> | 23 | 2021 | R | 93 | 24 | 0 | 2 | 1 | 3.52 | .276 | 1.08 | 6.9 | 3.0 | 10.5 | 30.2 | 23 | 12 | 12 | 5 | 10 | 35 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 4.03 |
| CL | Williams, D.Williams, Devin >> | 26 | 2021 | R | 84 | 17 | 0 | 0 | 4 | 7.41 | .320 | 1.41 | 9.0 | 3.7 | 13.8 | 17.0 | 17 | 14 | 14 | 2 | 7 | 26 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 2.71 |
| RP | Karinchak, J.Karinchak, James >> | 25 | 2021 | R | 82 | 20 | 0 | 1 | 2 | 4.91 | .298 | 1.27 | 9.0 | 2.5 | 11.5 | 22.0 | 22 | 12 | 12 | 4 | 6 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.64 |
| SP | Patino, L.Patino, Luis >> | 21 | 2021 | R | 55 | 2 | 0 | 0 | 0 | 0.00 | .250 | 1.00 | 5.4 | 3.6 | 9.9 | 10.0 | 6 | 0 | 0 | 0 | 4 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| SP | Plesac, Z.Plesac, Zach >> | 26 | 2021 | R | 56 | 4 | 0 | 0 | 0 | 0.00 | .400 | 2.00 | 9.0 | 9.0 | 6.0 | 3.0 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.67 |