| SP | Rodon, C.Rodon, Carlos >> | 28 | 2021 | L | 99 | 8 | 8 | 1 | 0 | 3.45 | .345 | 1.56 | 10.6 | 3.5 | 11.7 | 44.1 | 52 | 17 | 17 | 5 | 17 | 57 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 3.11 |
| SP | Burnes, C.Burnes, Corbin >> | 26 | 2021 | R | 97 | 8 | 8 | 5 | 0 | 1.16 | .238 | 0.94 | 6.3 | 2.2 | 12.2 | 54.1 | 38 | 12 | 7 | 3 | 13 | 73 | 1 | 0 | 0 | 1 | 6 | 0 | 0 | 1.74 |
| SP | Giolito, L.Giolito, Lucas >> | 26 | 2021 | R | 85 | 8 | 8 | 1 | 4 | 3.61 | .346 | 1.52 | 10.0 | 3.8 | 10.5 | 47.1 | 52 | 20 | 19 | 5 | 20 | 55 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 3.51 |
| SP | Garcia, L.Garcia, Luis >> | 24 | 2021 | R | 78 | 7 | 7 | 1 | 1 | 4.76 | .358 | 1.62 | 9.8 | 4.8 | 7.7 | 34.0 | 37 | 22 | 18 | 3 | 18 | 29 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 4.21 |
| CL | Kittredge, A.Kittredge, Andrew >> | 31 | 2021 | R | 86 | 22 | 0 | 2 | 3 | 6.92 | .350 | 1.54 | 10.0 | 3.8 | 8.3 | 26.0 | 29 | 22 | 20 | 8 | 11 | 24 | 0 | 3 | 2 | 0 | 0 | 2 | 2 | 6.65 |
| RP | Rasmussen, D.Rasmussen, Drew >> | 25 | 2021 | R | 81 | 22 | 0 | 5 | 2 | 3.00 | .288 | 1.14 | 7.3 | 3.0 | 6.2 | 42.0 | 34 | 16 | 14 | 7 | 14 | 29 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 5.00 |
| SU | Melancon, M.Melancon, Mark >> | 36 | 2021 | R | 57 | 19 | 0 | 1 | 1 | 3.16 | .287 | 1.21 | 8.6 | 2.5 | 10.1 | 25.2 | 24 | 11 | 9 | 3 | 7 | 28 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 3.16 |
| SP | Valdez, F.Valdez, Framber >> | 27 | 2021 | L | 65 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Castillo, L.Castillo, Luis >> | 28 | 2021 | R | 38 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | - | - | - | 0.2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Paddack, C.Paddack, Chris >> | 25 | 2021 | R | 40 | 2 | 0 | 0 | 1 | 32.40 | .583 | 4.20 | 54.0 | 9.0 | 9.0 | 1.2 | 6 | 6 | 6 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 43.00 |
| SP | Mikolas, M.Mikolas, Miles >> | 32 | 2021 | R | 52 | 4 | 0 | 0 | 1 | 1.23 | .290 | 1.23 | 7.7 | 3.9 | 6.4 | 7.1 | 6 | 2 | 1 | 1 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.71 |
| SP | Manning, M.Manning, Matt >> | 23 | 2021 | R | 16 | 14 | 0 | 3 | 1 | 4.58 | .344 | 1.53 | 9.9 | 4.3 | 9.0 | 19.2 | 21 | 11 | 10 | 2 | 9 | 19 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.95 |