| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 100 | 8 | 8 | 4 | 2 | 3.73 | .303 | 1.26 | 8.6 | 2.9 | 11.0 | 50.2 | 48 | 26 | 21 | 10 | 16 | 61 | 0 | 0 | 0 | 0 | 5 | 2 | 4 | 4.24 |
| SP | Morton, C.Morton, Charlie >> | 38 | 2021 | R | 95 | 8 | 8 | 3 | 2 | 4.04 | .307 | 1.33 | 8.1 | 3.9 | 9.0 | 49.0 | 44 | 25 | 22 | 6 | 21 | 49 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 3.88 |
| SP | Wheeler, Z.Wheeler, Zack >> | 31 | 2021 | R | 93 | 7 | 7 | 2 | 3 | 4.21 | .309 | 1.34 | 8.8 | 3.3 | 9.6 | 47.0 | 46 | 22 | 22 | 8 | 17 | 50 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.17 |
| CL | Romano, J.Romano, Jordan >> | 28 | 2021 | R | 93 | 16 | 0 | 1 | 2 | 3.63 | .307 | 1.33 | 8.5 | 3.7 | 10.6 | 17.1 | 16 | 7 | 7 | 2 | 7 | 20 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 3.41 |
| RP | Taillon, J.Taillon, Jameson >> | 29 | 2021 | R | 57 | 17 | 0 | 1 | 1 | 2.91 | .315 | 1.35 | 9.3 | 2.9 | 10.9 | 34.0 | 35 | 14 | 11 | 4 | 11 | 41 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.18 |
| RP | Kluber, C.Kluber, Corey >> | 35 | 2021 | R | 45 | 14 | 0 | 2 | 2 | 4.03 | .351 | 1.62 | 11.2 | 3.4 | 12.1 | 29.0 | 36 | 15 | 13 | 3 | 11 | 39 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 2.79 |
| RP | Ottavino, A.Ottavino, Adam >> | 35 | 2021 | R | 41 | 11 | 0 | 0 | 0 | 2.08 | .350 | 1.50 | 10.1 | 4.5 | 15.8 | 8.2 | 9 | 2 | 2 | 2 | 4 | 14 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 4.63 |
| SP | Luzardo, J.Luzardo, Jesus >> | 23 | 2021 | L | 19 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Stroman, M.Stroman, Marcus >> | 30 | 2021 | R | 71 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |