| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 34 | 34 | 11 | 14 | 4.22 | .297 | 1.24 | 8.2 | 3.0 | 9.6 | 219.2 | 200 | 106 | 103 | 25 | 73 | 233 | 2 | 0 | 0 | 0 | 20 | 6 | 5 | 3.44 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 6 | 16 | 5.82 | .330 | 1.44 | 9.4 | 3.6 | 8.9 | 199.1 | 208 | 138 | 129 | 34 | 79 | 196 | 3 | 0 | 0 | 1 | 10 | 7 | 0 | 4.55 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 32 | 32 | 10 | 15 | 4.66 | .319 | 1.38 | 8.7 | 3.8 | 6.0 | 210.2 | 203 | 125 | 109 | 24 | 88 | 140 | 3 | 0 | 0 | 0 | 16 | 5 | 5 | 4.48 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 31 | 31 | 12 | 13 | 4.76 | .321 | 1.40 | 9.8 | 2.8 | 3.7 | 215.2 | 235 | 123 | 114 | 29 | 68 | 88 | 11 | 0 | 0 | 3 | 14 | 3 | 10 | 4.93 |
| RP | Wagner, B.Wagner, Billy # >> | 28 | 1999 | L | 95 | 84 | 0 | 3 | 4 | 3.90 | .298 | 1.27 | 8.0 | 3.4 | 10.8 | 122.1 | 109 | 55 | 53 | 18 | 46 | 147 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 3.66 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 54 | 0 | 0 | 4 | 3.50 | .294 | 1.22 | 8.1 | 3.0 | 9.1 | 61.2 | 55 | 24 | 24 | 10 | 20 | 62 | 0 | 6 | 1 | 0 | 0 | 2 | 1 | 4.18 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 48 | 0 | 6 | 7 | 2.99 | .321 | 1.41 | 6.5 | 6.2 | 6.8 | 75.1 | 54 | 26 | 25 | 5 | 52 | 57 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 4.47 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 13 | 0 | 1 | 4 | 7.89 | .355 | 1.65 | 10.2 | 5.0 | 6.2 | 29.2 | 33 | 26 | 26 | 10 | 16 | 20 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 7.76 |