| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 39 | 39 | 18 | 12 | 3.27 | .273 | 1.11 | 7.9 | 2.1 | 7.8 | 291.1 | 255 | 110 | 106 | 38 | 67 | 253 | 10 | 0 | 0 | 2 | 28 | 7 | 4 | 3.72 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 35 | 35 | 11 | 18 | 5.07 | .323 | 1.40 | 9.5 | 3.1 | 4.6 | 209.1 | 221 | 125 | 118 | 24 | 73 | 107 | 0 | 0 | 0 | 0 | 15 | 5 | 3 | 4.59 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 34 | 34 | 13 | 12 | 4.92 | .338 | 1.50 | 10.0 | 3.5 | 4.8 | 219.1 | 243 | 127 | 120 | 18 | 86 | 117 | 7 | 0 | 0 | 2 | 13 | 7 | 13 | 4.27 |
| SP | Coveleski, S.Coveleski, Stan # >> | 28 | 1917 | R | 62 | 31 | 31 | 12 | 13 | 5.42 | .341 | 1.54 | 9.6 | 4.3 | 4.4 | 192.2 | 204 | 133 | 116 | 23 | 92 | 94 | 1 | 0 | 0 | 0 | 14 | 3 | 6 | 5.06 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 94 | 0 | 9 | 2 | 3.02 | .282 | 1.17 | 6.7 | 3.8 | 8.3 | 122.0 | 91 | 43 | 41 | 7 | 52 | 112 | 0 | 14 | 3 | 0 | 0 | 1 | 2 | 3.21 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 76 | 0 | 5 | 5 | 4.00 | .291 | 1.19 | 8.0 | 2.8 | 7.6 | 87.2 | 77 | 40 | 39 | 11 | 27 | 73 | 0 | 8 | 2 | 0 | 0 | 4 | 3 | 4.03 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 58 | 0 | 5 | 2 | 3.20 | .306 | 1.32 | 7.2 | 4.8 | 4.8 | 78.2 | 62 | 35 | 28 | 7 | 42 | 42 | 0 | 8 | 2 | 0 | 0 | 0 | 1 | 4.71 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 1 | 1 | 0 | 0 | 3.68 | .241 | 0.95 | 6.4 | 2.6 | 3.9 | 7.1 | 5 | 3 | 3 | 2 | 2 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6.71 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 57 | 2 | 0 | 0 | 0 | 4.91 | .421 | 2.18 | 21.0 | 3.0 | 0.0 | 3.2 | 7 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 59 | 20 | 0 | 0 | 4 | 7.84 | .367 | 1.74 | 11.0 | 4.6 | 7.3 | 31.0 | 38 | 29 | 27 | 6 | 16 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.45 |