| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 11 | 13 | 4.02 | .289 | 1.17 | 7.8 | 2.8 | 9.8 | 176.2 | 152 | 85 | 79 | 18 | 55 | 192 | 2 | 0 | 0 | 0 | 15 | 8 | 0 | 3.22 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 26 | 26 | 4 | 11 | 6.50 | .359 | 1.64 | 11.4 | 3.3 | 4.8 | 133.0 | 169 | 103 | 96 | 24 | 49 | 71 | 0 | 0 | 0 | 0 | 3 | 5 | 2 | 5.50 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 26 | 26 | 7 | 18 | 6.60 | .375 | 1.75 | 10.5 | 5.2 | 6.2 | 169.0 | 197 | 132 | 124 | 29 | 98 | 117 | 4 | 0 | 0 | 0 | 8 | 9 | 11 | 5.75 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 26 | 26 | 4 | 12 | 6.43 | .336 | 1.49 | 10.5 | 3.0 | 7.8 | 155.1 | 180 | 118 | 111 | 24 | 51 | 134 | 1 | 0 | 0 | 0 | 12 | 5 | 4 | 4.37 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 65 | 0 | 1 | 3 | 3.24 | .292 | 1.20 | 8.6 | 2.3 | 7.8 | 83.1 | 79 | 34 | 30 | 8 | 21 | 72 | 0 | 8 | 2 | 0 | 0 | 3 | 0 | 3.39 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 45 | 0 | 2 | 3 | 2.75 | .303 | 1.24 | 6.9 | 4.3 | 3.8 | 59.0 | 45 | 22 | 18 | 5 | 28 | 25 | 0 | 6 | 1 | 0 | 0 | 4 | 0 | 4.88 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 54 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 59 | 24 | 0 | 4 | 1 | 3.44 | .282 | 1.18 | 10.1 | 0.5 | 8.5 | 34.0 | 38 | 13 | 13 | 4 | 2 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 2.82 |