| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 35 | 35 | 12 | 7 | 3.86 | .281 | 1.14 | 7.9 | 2.3 | 7.4 | 226.1 | 199 | 99 | 97 | 25 | 59 | 185 | 5 | 0 | 0 | 0 | 19 | 7 | 6 | 3.68 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 85 | 34 | 34 | 9 | 13 | 4.33 | .312 | 1.35 | 8.9 | 3.2 | 4.0 | 214.0 | 212 | 107 | 103 | 28 | 76 | 95 | 4 | 0 | 0 | 0 | 20 | 3 | 4 | 4.92 |
| SP | Alexander, P.Alexander, Pete $ >> | 28 | 1915 | R | 88 | 33 | 33 | 12 | 9 | 4.39 | .290 | 1.22 | 8.3 | 2.7 | 3.6 | 207.0 | 191 | 103 | 101 | 19 | 62 | 82 | 8 | 0 | 0 | 4 | 14 | 1 | 5 | 4.31 |
| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 77 | 34 | 33 | 19 | 10 | 4.00 | .317 | 1.37 | 8.7 | 3.7 | 5.7 | 249.2 | 242 | 114 | 111 | 23 | 101 | 159 | 14 | 0 | 1 | 1 | 20 | 4 | 11 | 4.19 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 79 | 0 | 5 | 9 | 2.77 | .257 | 1.03 | 7.1 | 2.1 | 8.0 | 97.1 | 77 | 31 | 30 | 5 | 23 | 86 | 0 | 11 | 3 | 0 | 0 | 1 | 0 | 2.64 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 38 | 0 | 3 | 4 | 2.74 | .275 | 1.14 | 7.5 | 2.8 | 6.2 | 49.1 | 41 | 15 | 15 | 4 | 15 | 34 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.59 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 24 | 0 | 2 | 1 | 3.38 | .279 | 1.13 | 6.2 | 4.2 | 5.9 | 26.2 | 18 | 10 | 10 | 4 | 12 | 17 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 5.19 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 9 | 0 | 0 | 0 | 0.00 | .065 | 0.10 | 1.0 | 0.0 | 10.0 | 9.2 | 1 | 0 | 0 | 0 | 0 | 10 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1.11 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 29 | 0 | 7 | 2 | 3.16 | .277 | 1.09 | 6.4 | 3.4 | 8.1 | 74.0 | 53 | 27 | 26 | 7 | 28 | 67 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 3.72 |