| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 27 | 27 | 12 | 9 | 4.13 | .302 | 1.28 | 9.0 | 2.5 | 7.3 | 174.1 | 174 | 90 | 80 | 19 | 49 | 142 | 5 | 0 | 0 | 0 | 14 | 3 | 2 | 3.68 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 26 | 26 | 10 | 6 | 3.97 | .303 | 1.27 | 8.8 | 2.7 | 7.8 | 165.1 | 161 | 74 | 73 | 19 | 49 | 143 | 1 | 0 | 0 | 0 | 14 | 6 | 3 | 3.76 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 26 | 26 | 7 | 7 | 4.83 | .312 | 1.35 | 9.7 | 2.5 | 4.8 | 175.1 | 188 | 100 | 94 | 32 | 48 | 93 | 3 | 0 | 0 | 0 | 10 | 3 | 3 | 5.19 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 71 | 27 | 25 | 12 | 10 | 4.64 | .321 | 1.40 | 10.2 | 2.4 | 4.7 | 155.1 | 175 | 85 | 80 | 19 | 42 | 81 | 5 | 0 | 0 | 2 | 12 | 3 | 6 | 4.42 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 68 | 0 | 6 | 4 | 3.43 | .235 | 0.89 | 5.8 | 2.3 | 8.2 | 76.0 | 49 | 29 | 29 | 12 | 19 | 69 | 0 | 35 | 4 | 0 | 0 | 2 | 1 | 4.07 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 66 | 0 | 2 | 8 | 6.42 | .378 | 1.79 | 10.1 | 6.2 | 7.7 | 68.2 | 76 | 51 | 49 | 10 | 47 | 58 | 0 | 2 | 6 | 0 | 0 | 2 | 0 | 5.37 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 57 | 0 | 8 | 1 | 4.20 | .283 | 1.18 | 8.3 | 2.4 | 10.0 | 64.1 | 59 | 32 | 30 | 6 | 17 | 71 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 2.80 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 42 | 0 | 3 | 2 | 5.56 | .335 | 1.49 | 9.2 | 4.3 | 8.3 | 55.0 | 56 | 34 | 34 | 5 | 26 | 51 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.80 |