| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 100 | 33 | 33 | 14 | 7 | 3.34 | .288 | 1.20 | 8.0 | 2.9 | 9.0 | 207.1 | 183 | 86 | 77 | 30 | 66 | 207 | 1 | 0 | 0 | 1 | 25 | 2 | 4 | 3.87 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 80 | 33 | 33 | 9 | 14 | 4.87 | .320 | 1.40 | 9.0 | 3.6 | 3.9 | 194.0 | 194 | 128 | 105 | 32 | 77 | 83 | 5 | 0 | 0 | 0 | 15 | 3 | 10 | 5.53 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 80 | 32 | 32 | 11 | 11 | 5.02 | .313 | 1.34 | 9.1 | 3.1 | 8.3 | 174.0 | 175 | 104 | 97 | 28 | 59 | 160 | 0 | 0 | 0 | 0 | 15 | 4 | 1 | 4.34 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 65 | 32 | 32 | 9 | 10 | 4.96 | .319 | 1.39 | 9.1 | 3.3 | 4.4 | 187.0 | 190 | 121 | 103 | 38 | 69 | 92 | 0 | 0 | 0 | 0 | 15 | 4 | 5 | 5.83 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 29 | 5 | 7 | 5 | 3.32 | .293 | 1.23 | 6.2 | 4.9 | 7.9 | 124.2 | 86 | 49 | 46 | 8 | 67 | 109 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 3.75 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 74 | 95 | 0 | 4 | 2 | 3.89 | .338 | 1.53 | 9.3 | 4.7 | 9.3 | 71.2 | 73 | 38 | 31 | 11 | 37 | 73 | 0 | 1 | 2 | 0 | 0 | 0 | 8 | 4.52 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 73 | 88 | 0 | 2 | 7 | 4.34 | .290 | 1.20 | 8.5 | 2.3 | 7.4 | 85.0 | 80 | 48 | 41 | 11 | 22 | 70 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 3.88 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 59 | 62 | 0 | 4 | 8 | 6.12 | .337 | 1.45 | 9.0 | 4.2 | 4.3 | 67.2 | 67 | 51 | 46 | 20 | 31 | 32 | 0 | 20 | 8 | 0 | 0 | 5 | 2 | 7.54 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 89 | 63 | 0 | 4 | 3 | 3.19 | .279 | 1.15 | 7.5 | 2.9 | 8.8 | 59.1 | 49 | 26 | 21 | 7 | 19 | 58 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.59 |
| SP | Taylor, J.Taylor, Jack # >> | 28 | 1902 | R | 32 | 27 | 25 | 2 | 15 | 6.55 | .345 | 1.56 | 10.9 | 3.2 | 3.1 | 137.1 | 166 | 120 | 100 | 32 | 48 | 47 | 2 | 1 | 0 | 2 | 4 | 3 | 3 | 6.47 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 52 | 54 | 0 | 2 | 3 | 4.53 | .335 | 1.47 | 9.2 | 4.3 | 9.2 | 59.2 | 60 | 39 | 30 | 13 | 28 | 60 | 0 | 8 | 1 | 0 | 0 | 2 | 0 | 5.36 |
| RP | McMahon, D.McMahon, Don >> | 37 | 1967 | R | 42 | 10 | 0 | 1 | 2 | 5.25 | .321 | 1.42 | 9.8 | 3.0 | 6.8 | 12.0 | 13 | 7 | 7 | 4 | 4 | 9 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 6.83 |