| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 22 | 22 | 14 | 5 | 3.27 | .266 | 1.08 | 7.8 | 2.0 | 11.5 | 145.2 | 126 | 53 | 53 | 12 | 32 | 186 | 0 | 0 | 0 | 0 | 15 | 0 | 4 | 2.17 |
| SP | Crochet, G.Crochet, Garrett # >> | 26 | 2025 | L | 89 | 22 | 22 | 13 | 6 | 3.88 | .276 | 1.13 | 8.2 | 1.9 | 11.4 | 139.1 | 127 | 64 | 60 | 19 | 30 | 176 | 0 | 0 | 0 | 0 | 13 | 2 | 1 | 2.94 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 82 | 21 | 21 | 7 | 10 | 5.56 | .355 | 1.59 | 10.8 | 3.6 | 9.9 | 123.0 | 147 | 78 | 76 | 21 | 49 | 135 | 0 | 0 | 0 | 0 | 9 | 7 | 2 | 4.39 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 67 | 19 | 19 | 6 | 7 | 6.07 | .324 | 1.39 | 9.3 | 3.3 | 8.7 | 102.1 | 105 | 71 | 69 | 22 | 37 | 99 | 0 | 0 | 0 | 0 | 8 | 5 | 1 | 5.10 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 49 | 0 | 3 | 0 | 4.82 | .351 | 1.61 | 10.3 | 4.2 | 8.8 | 56.0 | 64 | 30 | 30 | 11 | 26 | 55 | 0 | 1 | 4 | 0 | 0 | 1 | 3 | 5.04 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 71 | 41 | 0 | 3 | 1 | 4.33 | .314 | 1.35 | 8.0 | 4.4 | 9.0 | 43.2 | 38 | 22 | 21 | 4 | 21 | 43 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.74 |
| CL | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 47 | 0 | 2 | 4 | 1.58 | .259 | 0.99 | 5.4 | 3.6 | 10.8 | 45.2 | 27 | 10 | 8 | 4 | 18 | 54 | 0 | 30 | 1 | 0 | 0 | 3 | 0 | 3.16 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 92 | 26 | 0 | 1 | 1 | 3.66 | .278 | 1.13 | 7.6 | 2.5 | 6.8 | 32.0 | 27 | 14 | 13 | 3 | 9 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.66 |
| SU | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 36 | 0 | 0 | 1 | 3.35 | .297 | 1.21 | 7.0 | 4.1 | 9.9 | 40.1 | 31 | 15 | 15 | 5 | 18 | 44 | 0 | 4 | 4 | 0 | 0 | 2 | 1 | 3.93 |