| SP | Johnson, R.Johnson, Randy + >> | 42 | 2005 | L | 93 | 10 | 10 | 2 | 6 | 5.54 | .337 | 1.52 | 11.1 | 2.6 | 6.2 | 65.0 | 80 | 42 | 40 | 16 | 19 | 45 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 5.69 |
| SP | Beckett, J.Beckett, Josh + >> | 25 | 2005 | R | 92 | 10 | 10 | 2 | 6 | 5.31 | .329 | 1.42 | 9.6 | 3.3 | 6.1 | 62.2 | 66 | 43 | 37 | 7 | 23 | 42 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 4.37 |
| SP | Willis, D.Willis, Dontrelle + >> | 23 | 2005 | L | 92 | 10 | 10 | 1 | 7 | 5.05 | .321 | 1.29 | 9.1 | 2.5 | 6.5 | 71.1 | 72 | 40 | 40 | 13 | 20 | 51 | 1 | 0 | 0 | 0 | 5 | 9 | 1 | 5.17 |
| SP | Smoltz, J.Smoltz, John + >> | 38 | 2005 | R | 90 | 10 | 10 | 5 | 2 | 3.86 | .302 | 1.27 | 9.4 | 2.1 | 6.6 | 72.1 | 75 | 32 | 31 | 12 | 17 | 53 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 4.49 |
| SP | Burnett, A.Burnett, A.J. >> | 28 | 2005 | R | 85 | 22 | 20 | 7 | 8 | 5.52 | .358 | 1.64 | 10.8 | 4.1 | 6.2 | 102.2 | 122 | 65 | 63 | 7 | 46 | 70 | 1 | 1 | 0 | 1 | 5 | 4 | 3 | 3.99 |
| RP | Turnbow, D.Turnbow, Derrick + >> | 27 | 2005 | R | 96 | 39 | 0 | 3 | 2 | 3.68 | .286 | 1.17 | 8.0 | 2.8 | 5.3 | 36.2 | 32 | 15 | 15 | 3 | 11 | 21 | 0 | 1 | 4 | 0 | 0 | 1 | 3 | 3.92 |
| RP | Hermanson, D.Hermanson, Dustin >> | 33 | 2005 | R | 86 | 52 | 0 | 1 | 3 | 6.71 | .371 | 1.71 | 10.9 | 4.8 | 5.4 | 53.2 | 64 | 40 | 40 | 6 | 28 | 32 | 0 | 3 | 1 | 0 | 0 | 3 | 2 | 5.02 |
| RP | Guardado, E.Guardado, Eddie >> | 35 | 2005 | L | 81 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Buehrle, M.Buehrle, Mark >> | 26 | 2005 | L | 78 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SU | Hoffman, T.Hoffman, Trevor >> | 38 | 2005 | R | 89 | 50 | 0 | 2 | 5 | 4.66 | .336 | 1.50 | 9.6 | 3.9 | 7.1 | 56.0 | 60 | 31 | 29 | 7 | 24 | 44 | 0 | 21 | 3 | 0 | 0 | 1 | 0 | 4.39 |
| CL | Isringhausen, J.Isringhausen, Jason >> | 33 | 2005 | R | 90 | 42 | 0 | 1 | 3 | 6.10 | .383 | 1.83 | 9.8 | 6.7 | 6.9 | 59.0 | 64 | 43 | 40 | 7 | 44 | 45 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.36 |