| SP | Peavy, J.Peavy, Jake + >> | 24 | 2005 | R | 98 | 21 | 21 | 11 | 5 | 4.63 | .321 | 1.38 | 9.1 | 3.4 | 9.2 | 114.2 | 115 | 67 | 59 | 13 | 43 | 117 | 3 | 0 | 0 | 1 | 8 | 5 | 1 | 3.69 |
| SP | Escobar, K.Escobar, Kelvim + >> | 29 | 2005 | R | 98 | 20 | 20 | 3 | 5 | 4.48 | .334 | 1.47 | 8.4 | 4.8 | 8.2 | 80.1 | 75 | 47 | 40 | 9 | 43 | 73 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 4.36 |
| SP | Liriano, F.Liriano, Francisco + >> | 22 | 2005 | L | 96 | 24 | 10 | 5 | 1 | 4.15 | .309 | 1.31 | 8.7 | 3.2 | 12.4 | 80.1 | 77 | 40 | 37 | 9 | 28 | 110 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 2.88 |
| SP | Prior, M.Prior, Mark + >> | 25 | 2005 | R | 90 | 19 | 19 | 7 | 6 | 5.81 | .346 | 1.55 | 10.9 | 3.2 | 9.6 | 100.2 | 121 | 66 | 65 | 15 | 35 | 107 | 0 | 0 | 0 | 0 | 6 | 4 | 1 | 3.98 |
| RP | Medders, B.Medders, Brandon + >> | 25 | 2005 | R | 99 | 50 | 0 | 4 | 5 | 2.80 | .277 | 1.13 | 6.5 | 3.7 | 8.0 | 61.0 | 44 | 20 | 19 | 3 | 25 | 54 | 0 | 19 | 0 | 0 | 0 | 1 | 1 | 3.15 |
| RP | Rhodes, A.Rhodes, Arthur + >> | 36 | 2005 | L | 98 | 54 | 0 | 2 | 3 | 4.42 | .335 | 1.46 | 9.9 | 3.2 | 7.6 | 59.0 | 65 | 29 | 29 | 11 | 21 | 50 | 0 | 2 | 4 | 0 | 0 | 3 | 0 | 4.95 |
| RP | Valverde, J.Valverde, Jose + >> | 26 | 2005 | R | 95 | 49 | 0 | 2 | 2 | 7.24 | .376 | 1.76 | 9.7 | 6.1 | 9.9 | 41.0 | 44 | 33 | 33 | 9 | 28 | 45 | 0 | 5 | 5 | 0 | 0 | 2 | 1 | 5.85 |
| RP | Rodriguez, F.Rodriguez, Francisco + >> | 23 | 2005 | R | 94 | 50 | 0 | 4 | 1 | 6.80 | .362 | 1.65 | 10.5 | 4.5 | 8.1 | 42.1 | 49 | 33 | 32 | 9 | 21 | 38 | 0 | 2 | 1 | 0 | 0 | 2 | 4 | 5.62 |
| RP | Linebrink, S.Linebrink, Scott + >> | 29 | 2005 | R | 97 | 62 | 0 | 7 | 3 | 6.88 | .376 | 1.78 | 11.3 | 4.9 | 7.3 | 70.2 | 88 | 58 | 54 | 14 | 38 | 57 | 0 | 2 | 5 | 0 | 0 | 2 | 4 | 5.69 |
| SP | Pettitte, A.Pettitte, Andy + >> | 33 | 2005 | L | 95 | 21 | 21 | 8 | 6 | 4.01 | .285 | 1.14 | 7.9 | 2.4 | 8.5 | 132.1 | 116 | 63 | 59 | 18 | 35 | 124 | 3 | 0 | 0 | 1 | 13 | 7 | 1 | 3.85 |
| SP | Myers, B.Myers, Brett + >> | 25 | 2005 | R | 89 | 21 | 10 | 5 | 4 | 4.18 | .323 | 1.42 | 8.3 | 4.5 | 7.1 | 90.1 | 83 | 44 | 42 | 8 | 45 | 71 | 0 | 2 | 0 | 0 | 7 | 1 | 3 | 4.11 |
| RP | Gordon, T.Gordon, Tom + >> | 38 | 2005 | R | 94 | 59 | 0 | 1 | 3 | 5.10 | .368 | 1.68 | 10.4 | 4.8 | 6.2 | 65.1 | 75 | 39 | 37 | 8 | 35 | 45 | 0 | 3 | 0 | 0 | 0 | 4 | 0 | 5.02 |