| SP | Sanchez, A.Sanchez, Anibal + >> | 22 | 2006 | R | 93 | 40 | 40 | 9 | 17 | 4.46 | .314 | 1.33 | 8.3 | 3.7 | 6.7 | 234.1 | 215 | 127 | 116 | 27 | 97 | 173 | 1 | 0 | 0 | 1 | 21 | 10 | 2 | 4.39 |
| SP | Karstens, J.Karstens, Jeff >> | 24 | 2006 | R | 84 | 20 | 20 | 3 | 9 | 7.52 | .394 | 1.89 | 12.4 | 4.6 | 5.5 | 79.0 | 109 | 72 | 66 | 15 | 40 | 48 | 0 | 0 | 0 | 0 | 4 | 5 | 6 | 5.96 |
| RP | Qualls, C.Qualls, Chad >> | 28 | 2006 | R | 88 | 106 | 0 | 6 | 7 | 3.40 | .318 | 1.37 | 9.0 | 3.3 | 6.6 | 132.1 | 132 | 62 | 50 | 10 | 49 | 97 | 0 | 10 | 7 | 0 | 0 | 4 | 0 | 3.72 |
| RP | Aardsma, D.Aardsma, David >> | 25 | 2006 | R | 89 | 70 | 0 | 1 | 5 | 5.06 | .331 | 1.47 | 8.2 | 5.1 | 6.8 | 83.2 | 76 | 50 | 47 | 7 | 47 | 63 | 0 | 4 | 1 | 0 | 0 | 1 | 2 | 4.31 |
| SP | Lackey, J.Lackey, John >> | 28 | 2006 | R | 90 | 41 | 40 | 13 | 16 | 5.76 | .357 | 1.64 | 11.5 | 3.3 | 6.7 | 211.0 | 270 | 146 | 135 | 17 | 77 | 158 | 2 | 1 | 0 | 0 | 13 | 5 | 6 | 3.72 |
| RP | Miller, M.Miller, Matt >> | 35 | 2006 | R | 84 | 88 | 0 | 2 | 7 | 5.36 | .376 | 1.76 | 10.4 | 5.6 | 6.6 | 90.2 | 104 | 65 | 54 | 13 | 56 | 66 | 0 | 5 | 0 | 0 | 0 | 4 | 0 | 5.41 |
| RP | Sanchez, D.Sanchez, Duaner >> | 27 | 2006 | R | 91 | 108 | 0 | 8 | 6 | 3.36 | .287 | 1.19 | 7.3 | 3.4 | 7.2 | 126.0 | 102 | 50 | 47 | 13 | 48 | 101 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 3.93 |
| SP | Johnson, J.Johnson, Josh >> | 22 | 2006 | R | 88 | 41 | 39 | 8 | 16 | 5.72 | .358 | 1.65 | 10.1 | 4.9 | 6.5 | 188.2 | 210 | 135 | 120 | 27 | 102 | 135 | 0 | 0 | 0 | 0 | 8 | 4 | 5 | 5.12 |
| SP | Gorzelanny, T.Gorzelanny, Tom >> | 24 | 2006 | L | 83 | 32 | 30 | 8 | 16 | 5.97 | .362 | 1.65 | 10.0 | 5.0 | 6.7 | 141.2 | 156 | 100 | 94 | 16 | 78 | 105 | 0 | 0 | 0 | 0 | 10 | 7 | 4 | 4.79 |
| RP | Betancourt, R.Betancourt, Rafael >> | 31 | 2006 | R | 92 | 118 | 0 | 5 | 5 | 4.20 | .317 | 1.39 | 10.3 | 2.1 | 6.5 | 135.0 | 155 | 73 | 63 | 19 | 32 | 97 | 0 | 7 | 5 | 0 | 0 | 1 | 0 | 4.13 |
| SP | Buchholz, T.Buchholz, Taylor >> | 25 | 2006 | R | 87 | 24 | 10 | 5 | 4 | 4.90 | .307 | 1.32 | 9.3 | 2.5 | 4.7 | 79.0 | 82 | 46 | 43 | 14 | 22 | 41 | 0 | 0 | 1 | 0 | 4 | 1 | 0 | 5.14 |