| SP | Zambrano, C.Zambrano, Carlos >> | 23 | 2004 | R | 98 | 58 | 58 | 19 | 22 | 3.55 | .300 | 1.27 | 7.5 | 3.9 | 6.7 | 383.1 | 318 | 164 | 151 | 23 | 167 | 287 | 0 | 0 | 0 | 0 | 35 | 8 | 8 | 3.65 |
| SP | Hernandez, L.Hernandez, Livan >> | 29 | 2004 | R | 92 | 57 | 57 | 23 | 24 | 4.66 | .325 | 1.41 | 9.5 | 3.2 | 6.0 | 372.2 | 393 | 204 | 193 | 42 | 134 | 249 | 10 | 0 | 0 | 1 | 28 | 12 | 6 | 4.31 |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 76 | 23 | 8 | 4 | 6 | 5.38 | .330 | 1.46 | 11.2 | 2.0 | 5.6 | 118.2 | 147 | 71 | 71 | 19 | 26 | 73 | 0 | 1 | 0 | 0 | 3 | 2 | 0 | 4.57 |
| SP | Maddux, G.Maddux, Greg >> | 38 | 2004 | R | 86 | 39 | 37 | 14 | 12 | 4.99 | .314 | 1.35 | 10.0 | 2.2 | 6.6 | 247.1 | 274 | 145 | 137 | 42 | 60 | 182 | 1 | 0 | 0 | 0 | 17 | 5 | 2 | 4.53 |
| RP | Brazoban, Y.Brazoban, Yhency >> | 24 | 2004 | R | 92 | 130 | 0 | 8 | 8 | 4.14 | .299 | 1.27 | 7.1 | 4.3 | 6.5 | 137.0 | 108 | 65 | 63 | 18 | 66 | 99 | 0 | 2 | 1 | 0 | 0 | 1 | 6 | 4.73 |
| RP | Carrara, G.Carrara, Giovanni >> | 36 | 2004 | R | 90 | 147 | 0 | 10 | 9 | 4.73 | .313 | 1.35 | 9.0 | 3.2 | 7.0 | 156.0 | 156 | 88 | 82 | 17 | 55 | 122 | 0 | 18 | 8 | 0 | 0 | 2 | 2 | 3.95 |
| RP | Torres, S.Torres, Salomon >> | 32 | 2004 | R | 84 | 46 | 0 | 1 | 2 | 3.14 | .318 | 1.38 | 8.1 | 4.5 | 6.2 | 48.2 | 43 | 20 | 17 | 1 | 24 | 33 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 3.46 |
| SP | Pavano, C.Pavano, Carl >> | 28 | 2004 | R | 90 | 51 | 50 | 23 | 17 | 4.41 | .316 | 1.37 | 9.5 | 2.8 | 5.8 | 361.1 | 382 | 184 | 177 | 45 | 114 | 233 | 8 | 0 | 0 | 3 | 25 | 5 | 5 | 4.32 |
| CL | Percival, T.Percival, Troy >> | 35 | 2004 | R | 84 | 62 | 0 | 5 | 11 | 5.30 | .363 | 1.69 | 10.0 | 5.3 | 5.5 | 54.1 | 60 | 35 | 32 | 8 | 32 | 33 | 0 | 28 | 6 | 0 | 0 | 1 | 0 | 5.54 |