| SP | Verlander, J.Verlander, Justin † >> | 28 | 2011 | R | 93 | 35 | 35 | 21 | 8 | 2.33 | .264 | 1.06 | 6.4 | 3.1 | 6.3 | 285.2 | 203 | 81 | 74 | 28 | 99 | 200 | 16 | 0 | 0 | 5 | 29 | 6 | 3 | 3.98 |
| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 96 | 34 | 34 | 16 | 12 | 4.16 | .279 | 1.15 | 8.5 | 1.9 | 9.1 | 218.1 | 206 | 105 | 101 | 20 | 46 | 221 | 2 | 0 | 0 | 0 | 19 | 2 | 4 | 2.83 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 87 | 33 | 33 | 9 | 14 | 4.78 | .306 | 1.30 | 8.4 | 3.3 | 8.1 | 216.1 | 201 | 117 | 115 | 17 | 80 | 194 | 2 | 0 | 0 | 0 | 19 | 5 | 5 | 3.41 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 84 | 33 | 33 | 11 | 13 | 5.31 | .320 | 1.40 | 10.3 | 2.3 | 8.8 | 188.0 | 216 | 114 | 111 | 24 | 48 | 184 | 0 | 0 | 0 | 0 | 14 | 2 | 9 | 3.50 |
| SP | Robinson, J.Robinson, Jeff † >> | 27 | 1988 | R | 55 | 31 | 31 | 14 | 12 | 4.34 | .325 | 1.44 | 7.8 | 5.1 | 5.3 | 203.1 | 177 | 103 | 98 | 19 | 115 | 119 | 5 | 0 | 0 | 3 | 16 | 2 | 9 | 4.77 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 74 | 90 | 0 | 6 | 5 | 1.85 | .258 | 1.03 | 6.5 | 2.8 | 8.5 | 117.0 | 84 | 28 | 24 | 9 | 37 | 110 | 0 | 11 | 6 | 0 | 0 | 1 | 0 | 3.09 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 55 | 77 | 0 | 8 | 3 | 2.57 | .280 | 1.15 | 5.6 | 4.7 | 5.3 | 91.0 | 57 | 27 | 26 | 0 | 48 | 54 | 0 | 16 | 2 | 0 | 0 | 1 | 3 | 3.43 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 57 | 49 | 0 | 2 | 4 | 2.64 | .308 | 1.30 | 8.7 | 3.1 | 6.2 | 61.1 | 59 | 18 | 18 | 5 | 21 | 42 | 0 | 8 | 0 | 0 | 0 | 2 | 7 | 3.82 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 54 | 19 | 0 | 3 | 2 | 4.50 | .275 | 1.14 | 5.7 | 4.5 | 6.1 | 22.0 | 14 | 14 | 11 | 2 | 11 | 15 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.32 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 40 | 12 | 0 | 2 | 0 | 1.69 | .186 | 0.63 | 5.1 | 0.6 | 7.3 | 16.0 | 9 | 3 | 3 | 2 | 1 | 13 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.38 |
| RP | Benoit, J.Benoit, Joaquin >> | 34 | 2011 | R | 37 | 14 | 0 | 0 | 0 | 16.55 | .523 | 3.29 | 27.0 | 3.6 | 4.5 | 10.1 | 30 | 19 | 19 | 1 | 4 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.50 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 89 | 26 | 0 | 1 | 0 | 2.42 | .258 | 1.03 | 6.4 | 2.8 | 5.8 | 67.0 | 48 | 22 | 18 | 8 | 21 | 43 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.25 |