| SP | Darvish, Y.Darvish, Yu † >> | 35 | 2022 | R | 83 | 19 | 19 | 9 | 7 | 3.24 | .254 | 1.01 | 6.9 | 2.1 | 8.1 | 139.0 | 107 | 52 | 50 | 16 | 33 | 125 | 2 | 0 | 0 | 0 | 13 | 2 | 5 | 3.45 |
| SP | Pivetta, N.Pivetta, Nick >> | 32 | 2025 | R | 82 | 18 | 18 | 7 | 8 | 3.43 | .282 | 1.15 | 7.3 | 3.1 | 8.8 | 110.1 | 89 | 44 | 42 | 10 | 38 | 107 | 0 | 0 | 0 | 0 | 12 | 3 | 4 | 3.35 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 80 | 18 | 18 | 9 | 7 | 5.33 | .316 | 1.38 | 8.9 | 3.5 | 7.5 | 103.0 | 102 | 62 | 61 | 18 | 40 | 86 | 0 | 0 | 0 | 0 | 7 | 1 | 3 | 4.80 |
| SP | Harris, G.Harris, Greg >> | 28 | 1991 | R | 55 | 17 | 17 | 8 | 7 | 4.11 | .325 | 1.42 | 9.9 | 3.0 | 5.3 | 122.2 | 134 | 66 | 56 | 15 | 40 | 72 | 2 | 0 | 0 | 1 | 9 | 3 | 5 | 4.48 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 98 | 53 | 0 | 4 | 3 | 3.30 | .301 | 1.26 | 6.0 | 5.5 | 9.3 | 62.2 | 41 | 24 | 23 | 2 | 38 | 64 | 0 | 6 | 0 | 0 | 0 | 2 | 2 | 3.29 |
| RP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 80 | 33 | 0 | 1 | 1 | 4.00 | .299 | 1.28 | 7.3 | 4.3 | 11.0 | 36.0 | 29 | 16 | 16 | 6 | 17 | 44 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.14 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 77 | 18 | 0 | 0 | 0 | 0.00 | .188 | 0.69 | 2.8 | 3.5 | 10.4 | 13.0 | 4 | 2 | 0 | 0 | 5 | 15 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 1.85 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 68 | 43 | 0 | 1 | 2 | 4.21 | .260 | 0.97 | 5.4 | 3.6 | 10.8 | 25.2 | 15 | 12 | 12 | 2 | 10 | 30 | 0 | 5 | 2 | 0 | 0 | 2 | 1 | 3.08 |
| RP | Andersen, L.Andersen, Larry >> | 39 | 1992 | R | 53 | 17 | 0 | 1 | 1 | 3.86 | .276 | 1.14 | 6.9 | 3.4 | 10.3 | 21.0 | 16 | 9 | 9 | 5 | 8 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.95 |