| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 100 | 33 | 33 | 21 | 5 | 2.83 | .260 | 1.03 | 6.7 | 2.6 | 8.3 | 242.0 | 180 | 79 | 76 | 18 | 70 | 224 | 3 | 0 | 0 | 1 | 22 | 5 | 4 | 3.05 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 33 | 33 | 20 | 3 | 4.11 | .304 | 1.29 | 8.2 | 3.4 | 7.9 | 212.1 | 194 | 103 | 97 | 16 | 79 | 185 | 0 | 0 | 0 | 0 | 17 | 5 | 4 | 3.42 |
| SP | deGrom, J.deGrom, Jacob >> | 30 | 2018 | R | 85 | 32 | 32 | 20 | 5 | 2.96 | .289 | 1.20 | 7.7 | 3.1 | 7.7 | 240.0 | 206 | 90 | 79 | 21 | 82 | 205 | 3 | 0 | 0 | 1 | 25 | 4 | 1 | 3.50 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 51 | 27 | 27 | 10 | 6 | 3.49 | .318 | 1.38 | 7.3 | 5.2 | 7.2 | 159.2 | 129 | 67 | 62 | 17 | 91 | 127 | 1 | 0 | 0 | 0 | 11 | 3 | 3 | 4.57 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 93 | 77 | 0 | 6 | 1 | 2.10 | .213 | 0.79 | 4.6 | 2.6 | 8.1 | 81.1 | 41 | 19 | 19 | 3 | 23 | 73 | 0 | 15 | 1 | 0 | 0 | 2 | 0 | 2.60 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 42 | 0 | 5 | 1 | 3.27 | .271 | 1.09 | 6.6 | 3.3 | 7.2 | 41.1 | 30 | 15 | 15 | 2 | 15 | 33 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 3.20 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 36 | 0 | 4 | 1 | 2.20 | .283 | 1.19 | 6.8 | 4.2 | 8.4 | 28.2 | 21 | 8 | 7 | 1 | 13 | 26 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.00 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 67 | 0 | 4 | 4 | 2.14 | .270 | 1.07 | 6.5 | 3.2 | 8.2 | 71.1 | 51 | 18 | 17 | 4 | 25 | 65 | 0 | 36 | 5 | 0 | 0 | 3 | 3 | 3.08 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 69 | 8 | 3 | 1 | 0 | 4.23 | .357 | 1.66 | 12.0 | 3.3 | 7.0 | 27.2 | 36 | 14 | 13 | 0 | 10 | 21 | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 2.56 |