| SP | Plesac, Z.Plesac, Zach + >> | 25 | 2020 | R | 95 | 18 | 18 | 4 | 5 | 4.19 | .313 | 1.33 | 9.5 | 2.5 | 9.4 | 92.1 | 97 | 46 | 43 | 14 | 26 | 96 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 3.84 |
| SP | Wacha, M.Wacha, Michael >> | 28 | 2014 | R | 90 | 17 | 17 | 7 | 5 | 2.82 | .259 | 1.04 | 7.6 | 1.8 | 6.4 | 121.1 | 102 | 44 | 38 | 12 | 24 | 86 | 3 | 0 | 0 | 1 | 13 | 1 | 1 | 3.49 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 30 | 2016 | R | 85 | 17 | 17 | 5 | 8 | 4.52 | .288 | 1.17 | 8.4 | 2.2 | 7.4 | 91.2 | 85 | 47 | 46 | 11 | 22 | 75 | 2 | 0 | 0 | 1 | 6 | 4 | 1 | 3.78 |
| RP | De La Rosa, R.De La Rosa, Rubby >> | 31 | 2011 | R | 87 | 39 | 0 | 5 | 5 | 4.37 | .288 | 1.19 | 8.1 | 2.7 | 9.5 | 78.1 | 70 | 39 | 38 | 10 | 23 | 82 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.53 |
| RP | Ramirez, N.Ramirez, Neil >> | 31 | 2014 | R | 88 | 27 | 0 | 4 | 1 | 4.36 | .340 | 1.55 | 9.8 | 4.1 | 10.9 | 33.0 | 36 | 19 | 16 | 8 | 15 | 40 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 5.09 |
| CL | Edwards, C.Edwards, Carl >> | 28 | 2016 | R | 100 | 38 | 0 | 3 | 1 | 4.38 | .297 | 1.22 | 8.5 | 2.4 | 10.9 | 37.0 | 35 | 18 | 18 | 3 | 10 | 45 | 0 | 23 | 5 | 0 | 0 | 2 | 4 | 2.59 |
| RP | Kahnle, T.Kahnle, Tommy >> | 30 | 2014 | R | 80 | 23 | 0 | 5 | 1 | 6.35 | .356 | 1.62 | 9.6 | 5.1 | 8.4 | 28.1 | 30 | 21 | 20 | 5 | 16 | 26 | 0 | 0 | 2 | 0 | 0 | 1 | 3 | 5.29 |
| RP | Kolarek, A.Kolarek, Adam >> | 31 | 2020 | L | 80 | 20 | 0 | 2 | 0 | 2.81 | .260 | 1.01 | 6.1 | 3.2 | 6.1 | 25.2 | 17 | 8 | 8 | 3 | 9 | 17 | 0 | 2 | 0 | 0 | 0 | 1 | 5 | 4.40 |
| SP | Arrieta, J.Arrieta, Jake >> | 34 | 2015 | R | 85 | 17 | 0 | 3 | 5 | 4.68 | .311 | 1.33 | 8.1 | 3.8 | 8.1 | 73.0 | 66 | 41 | 38 | 11 | 31 | 66 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.51 |
| SP | Richards, G.Richards, Garrett >> | 32 | 2014 | R | 83 | 15 | 14 | 4 | 3 | 4.66 | .327 | 1.46 | 9.6 | 3.7 | 8.9 | 63.2 | 67 | 33 | 33 | 7 | 26 | 62 | 0 | 0 | 0 | 0 | 6 | 0 | 7 | 3.71 |