| SP | Scherzer, M.Scherzer, Max >> | 38 | 2021 | R | 88 | 33 | 33 | 16 | 11 | 3.91 | .288 | 1.19 | 8.5 | 2.2 | 9.7 | 207.0 | 196 | 96 | 90 | 42 | 51 | 223 | 1 | 0 | 0 | 0 | 20 | 4 | 3 | 4.28 |
| SP | Verlander, J.Verlander, Justin >> | 39 | 2019 | R | 91 | 33 | 33 | 17 | 8 | 3.33 | .290 | 1.16 | 7.9 | 2.6 | 9.7 | 221.2 | 193 | 86 | 82 | 18 | 65 | 238 | 2 | 0 | 0 | 1 | 19 | 14 | 2 | 2.98 |
| SP | Fulmer, M.Fulmer, Michael # >> | 29 | 2016 | R | 79 | 32 | 32 | 11 | 17 | 5.23 | .315 | 1.35 | 9.8 | 2.4 | 7.7 | 199.2 | 216 | 118 | 116 | 33 | 53 | 171 | 3 | 0 | 0 | 1 | 14 | 6 | 3 | 4.33 |
| SP | Porcello, R.Porcello, Rick # >> | 33 | 2016 | R | 43 | 32 | 32 | 11 | 14 | 4.32 | .294 | 1.21 | 8.7 | 2.2 | 9.0 | 191.2 | 184 | 97 | 92 | 40 | 47 | 192 | 0 | 0 | 0 | 0 | 18 | 8 | 3 | 4.58 |
| RP | Rondon, B.Rondon, Bruce >> | 31 | 2013 | R | 91 | 85 | 0 | 4 | 3 | 2.13 | .242 | 0.92 | 5.3 | 3.1 | 10.4 | 144.0 | 84 | 37 | 34 | 11 | 49 | 167 | 0 | 2 | 1 | 0 | 0 | 5 | 7 | 2.80 |
| RP | Jimenez, J.Jimenez, Joe >> | 27 | 2018 | R | 74 | 65 | 0 | 5 | 7 | 4.85 | .301 | 1.27 | 8.5 | 2.9 | 10.5 | 78.0 | 74 | 50 | 42 | 23 | 25 | 91 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 5.54 |
| RP | Skubal, T.Skubal, Tarik >> | 25 | 2020 | L | 50 | 40 | 0 | 3 | 2 | 2.64 | .235 | 0.89 | 6.6 | 1.5 | 11.3 | 71.2 | 52 | 21 | 21 | 7 | 12 | 89 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2.37 |
| SU | Alcantara, V.Alcantara, Victor >> | 29 | 2018 | R | 68 | 58 | 0 | 0 | 3 | 3.77 | .298 | 1.24 | 7.7 | 3.5 | 5.2 | 62.0 | 53 | 27 | 26 | 8 | 24 | 36 | 0 | 4 | 4 | 0 | 0 | 2 | 2 | 4.77 |
| CL | Norris, D.Norris, Daniel >> | 29 | 2015 | L | 77 | 56 | 0 | 1 | 2 | 2.12 | .227 | 0.86 | 5.4 | 2.4 | 7.4 | 63.2 | 38 | 15 | 15 | 8 | 17 | 52 | 0 | 45 | 2 | 0 | 0 | 1 | 1 | 3.86 |