| SP | Scherzer, M.Scherzer, Max >> | 38 | 2021 | R | 88 | 11 | 11 | 5 | 5 | 3.76 | .293 | 1.21 | 9.4 | 1.6 | 10.3 | 69.1 | 72 | 31 | 29 | 14 | 12 | 79 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 3.96 |
| SP | Verlander, J.Verlander, Justin >> | 39 | 2019 | R | 91 | 11 | 11 | 7 | 3 | 2.81 | .264 | 1.03 | 6.4 | 2.8 | 10.2 | 77.0 | 55 | 25 | 24 | 4 | 24 | 87 | 1 | 0 | 0 | 0 | 7 | 4 | 0 | 2.51 |
| SP | Fulmer, M.Fulmer, Michael # >> | 29 | 2016 | R | 80 | 11 | 11 | 2 | 7 | 6.09 | .315 | 1.37 | 10.1 | 2.3 | 7.1 | 68.0 | 76 | 46 | 46 | 14 | 17 | 54 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 4.88 |
| SP | Porcello, R.Porcello, Rick # >> | 33 | 2016 | R | 43 | 10 | 10 | 4 | 5 | 5.50 | .299 | 1.22 | 8.8 | 2.2 | 8.8 | 54.0 | 53 | 35 | 33 | 15 | 13 | 53 | 0 | 0 | 0 | 0 | 5 | 3 | 3 | 5.54 |
| RP | Rondon, B.Rondon, Bruce >> | 31 | 2013 | R | 91 | 30 | 0 | 2 | 2 | 2.12 | .246 | 0.94 | 5.1 | 3.4 | 10.8 | 51.0 | 29 | 12 | 12 | 3 | 19 | 61 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 2.61 |
| RP | Jimenez, J.Jimenez, Joe >> | 27 | 2018 | R | 74 | 19 | 0 | 1 | 0 | 4.24 | .247 | 0.99 | 5.5 | 3.5 | 12.1 | 23.1 | 14 | 11 | 11 | 8 | 9 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| RP | Skubal, T.Skubal, Tarik >> | 25 | 2020 | L | 50 | 11 | 0 | 0 | 1 | 3.32 | .244 | 0.92 | 6.0 | 2.6 | 7.7 | 21.2 | 14 | 8 | 8 | 4 | 6 | 18 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.76 |
| SU | Alcantara, V.Alcantara, Victor >> | 29 | 2018 | R | 68 | 19 | 0 | 0 | 0 | 0.46 | .203 | 0.76 | 5.7 | 1.4 | 4.3 | 19.2 | 12 | 1 | 1 | 0 | 3 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.53 |
| CL | Norris, D.Norris, Daniel >> | 29 | 2015 | L | 77 | 19 | 0 | 0 | 0 | 0.49 | .214 | 0.82 | 4.0 | 3.5 | 6.0 | 18.1 | 8 | 1 | 1 | 0 | 7 | 12 | 0 | 17 | 0 | 0 | 0 | 0 | 0 | 2.83 |