| SP | Verlander, J.Verlander, Justin # >> | 28 | 2011 | R | 82 | 32 | 32 | 13 | 12 | 3.94 | .287 | 1.19 | 8.4 | 2.4 | 8.0 | 230.2 | 214 | 103 | 101 | 27 | 61 | 205 | 9 | 0 | 0 | 3 | 18 | 3 | 6 | 3.58 |
| SP | Skubal, T.Skubal, Tarik >> | 26 | 2023 | L | 84 | 31 | 31 | 0 | 5 | 2.81 | .300 | 1.28 | 8.6 | 3.0 | 8.5 | 83.1 | 79 | 29 | 26 | 8 | 28 | 78 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.39 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 31 | 30 | 12 | 13 | 5.07 | .313 | 1.36 | 10.0 | 2.3 | 6.6 | 209.2 | 232 | 133 | 118 | 34 | 53 | 154 | 9 | 1 | 0 | 2 | 10 | 2 | 3 | 4.43 |
| SP | Hiller, J.Hiller, John >> | 25 | 1968 | L | 49 | 30 | 30 | 2 | 5 | 5.45 | .370 | 1.70 | 10.1 | 5.2 | 6.3 | 104.0 | 117 | 68 | 63 | 13 | 60 | 73 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 5.13 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 58 | 30 | 29 | 13 | 9 | 4.75 | .319 | 1.38 | 10.0 | 2.5 | 8.9 | 168.2 | 186 | 92 | 89 | 20 | 47 | 166 | 1 | 1 | 0 | 1 | 16 | 4 | 3 | 3.48 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 65 | 98 | 0 | 12 | 4 | 3.18 | .308 | 1.32 | 8.0 | 3.9 | 4.5 | 113.1 | 101 | 45 | 40 | 9 | 49 | 56 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 4.37 |
| RP | Greene, S.Greene, Shane † >> | 30 | 2019 | R | 83 | 89 | 0 | 14 | 3 | 2.78 | .262 | 1.04 | 6.7 | 2.6 | 8.7 | 110.0 | 82 | 40 | 34 | 7 | 32 | 106 | 0 | 7 | 1 | 0 | 0 | 3 | 0 | 2.85 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 77 | 76 | 0 | 4 | 0 | 3.65 | .293 | 1.24 | 7.5 | 3.6 | 9.8 | 79.0 | 66 | 38 | 32 | 13 | 32 | 86 | 0 | 3 | 3 | 0 | 0 | 0 | 5 | 4.18 |
| RP | Alburquerque, A.Alburquerque, Al >> | 25 | 2011 | R | 60 | 77 | 0 | 7 | 4 | 3.52 | .277 | 1.14 | 6.3 | 4.0 | 10.2 | 92.0 | 64 | 38 | 36 | 11 | 41 | 104 | 0 | 9 | 1 | 0 | 0 | 1 | 4 | 3.66 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 62 | 67 | 0 | 4 | 4 | 4.60 | .292 | 1.22 | 7.5 | 3.5 | 8.5 | 74.1 | 62 | 39 | 38 | 15 | 29 | 70 | 0 | 9 | 1 | 0 | 0 | 1 | 1 | 4.96 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 68 | 55 | 0 | 8 | 4 | 4.41 | .350 | 1.59 | 10.2 | 4.2 | 6.6 | 83.2 | 94 | 47 | 41 | 9 | 39 | 61 | 0 | 3 | 4 | 0 | 0 | 2 | 7 | 4.42 |