| SP | Garland, J.Garland, Jon >> | 26 | 2005 | R | 53 | 36 | 36 | 14 | 16 | 4.41 | .302 | 1.28 | 9.0 | 2.5 | 5.9 | 243.0 | 243 | 120 | 119 | 35 | 67 | 159 | 3 | 0 | 0 | 1 | 18 | 5 | 4 | 4.45 |
| SP | Buehrle, M.Buehrle, Mark >> | 26 | 2005 | L | 49 | 35 | 35 | 9 | 13 | 4.03 | .299 | 1.25 | 9.0 | 2.3 | 6.8 | 252.2 | 252 | 113 | 113 | 29 | 64 | 189 | 0 | 0 | 0 | 0 | 20 | 7 | 5 | 3.84 |
| SP | McCarthy, B.McCarthy, Brandon >> | 22 | 2005 | R | 60 | 34 | 34 | 10 | 14 | 4.89 | .305 | 1.29 | 9.0 | 2.6 | 7.0 | 187.2 | 188 | 104 | 102 | 32 | 54 | 145 | 1 | 0 | 0 | 1 | 14 | 5 | 5 | 4.62 |
| SP | Contreras, J.Contreras, Jose >> | 34 | 2005 | R | 59 | 33 | 33 | 14 | 10 | 3.93 | .337 | 1.49 | 9.0 | 4.3 | 6.2 | 206.0 | 207 | 103 | 90 | 16 | 99 | 141 | 1 | 0 | 0 | 1 | 18 | 8 | 11 | 4.20 |
| SP | Garcia, F.Garcia, Freddy >> | 29 | 2005 | R | 41 | 27 | 24 | 10 | 10 | 5.09 | .323 | 1.40 | 8.7 | 3.9 | 7.1 | 169.2 | 163 | 100 | 96 | 26 | 74 | 133 | 2 | 0 | 0 | 1 | 8 | 6 | 10 | 4.85 |
| RP | Hermanson, D.Hermanson, Dustin >> | 33 | 2005 | R | 65 | 98 | 0 | 5 | 7 | 3.20 | .277 | 1.10 | 6.4 | 3.5 | 6.3 | 95.2 | 68 | 35 | 34 | 15 | 37 | 67 | 0 | 2 | 3 | 0 | 0 | 5 | 2 | 4.97 |
| CL | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 91 | 70 | 0 | 10 | 5 | 1.92 | .239 | 0.92 | 6.2 | 2.2 | 8.5 | 79.2 | 54 | 20 | 17 | 4 | 19 | 75 | 0 | 36 | 5 | 0 | 0 | 2 | 1 | 2.56 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 31 | 2005 | R | 18 | 54 | 0 | 2 | 1 | 3.70 | .263 | 1.05 | 6.6 | 3.0 | 7.1 | 48.2 | 35 | 20 | 20 | 6 | 16 | 38 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.10 |
| RP | Takatsu, S.Takatsu, Shingo >> | 37 | 2005 | R | 13 | 32 | 0 | 4 | 2 | 4.59 | .324 | 1.44 | 11.2 | 1.9 | 12.0 | 33.1 | 41 | 17 | 17 | 8 | 7 | 44 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.12 |
| RP | Marte, D.Marte, Damaso >> | 30 | 2005 | L | 19 | 72 | 0 | 1 | 1 | 4.21 | .358 | 1.64 | 9.0 | 5.8 | 10.2 | 51.1 | 51 | 24 | 24 | 7 | 33 | 58 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 4.57 |