| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 93 | 33 | 33 | 15 | 10 | 2.48 | .269 | 1.08 | 7.1 | 2.7 | 7.8 | 229.0 | 180 | 65 | 63 | 7 | 68 | 199 | 0 | 0 | 0 | 0 | 25 | 5 | 2 | 2.62 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 90 | 32 | 32 | 16 | 11 | 3.49 | .291 | 1.22 | 8.2 | 2.8 | 8.4 | 216.1 | 196 | 90 | 84 | 27 | 67 | 201 | 2 | 0 | 0 | 1 | 17 | 4 | 5 | 3.75 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 90 | 30 | 30 | 17 | 8 | 3.03 | .293 | 1.19 | 6.9 | 3.8 | 7.8 | 196.1 | 151 | 69 | 66 | 17 | 82 | 170 | 2 | 0 | 0 | 2 | 21 | 11 | 3 | 3.82 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 67 | 22 | 22 | 6 | 12 | 5.58 | .341 | 1.50 | 10.1 | 3.5 | 6.9 | 109.2 | 122 | 68 | 68 | 9 | 42 | 84 | 0 | 0 | 0 | 0 | 9 | 6 | 7 | 3.85 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 99 | 94 | 0 | 4 | 2 | 2.13 | .236 | 0.86 | 4.6 | 3.2 | 10.4 | 88.2 | 45 | 21 | 21 | 3 | 31 | 102 | 0 | 2 | 0 | 0 | 0 | 6 | 8 | 2.39 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 99 | 65 | 0 | 6 | 3 | 1.47 | .216 | 0.81 | 5.2 | 2.2 | 11.1 | 73.2 | 42 | 12 | 12 | 4 | 18 | 90 | 0 | 46 | 4 | 0 | 0 | 1 | 2 | 2.03 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 84 | 44 | 0 | 4 | 1 | 1.30 | .269 | 1.10 | 7.9 | 2.2 | 9.9 | 41.2 | 36 | 9 | 6 | 3 | 10 | 45 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.49 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 65 | 46 | 0 | 0 | 1 | 0.53 | .203 | 0.76 | 4.5 | 2.4 | 7.4 | 34.0 | 17 | 3 | 2 | 1 | 9 | 28 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 2.53 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 58 | 33 | 0 | 2 | 2 | 2.51 | .279 | 1.14 | 5.4 | 4.8 | 7.7 | 43.0 | 26 | 12 | 12 | 2 | 23 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.56 |