| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 92 | 35 | 35 | 16 | 11 | 2.49 | .269 | 1.08 | 7.1 | 2.7 | 7.8 | 242.1 | 190 | 70 | 67 | 8 | 72 | 211 | 0 | 0 | 0 | 0 | 27 | 5 | 3 | 2.64 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 88 | 35 | 35 | 18 | 12 | 3.61 | .296 | 1.24 | 8.3 | 2.8 | 8.1 | 232.0 | 215 | 100 | 93 | 30 | 73 | 210 | 2 | 0 | 0 | 1 | 18 | 4 | 5 | 3.87 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 89 | 33 | 33 | 19 | 8 | 2.80 | .289 | 1.17 | 6.9 | 3.7 | 7.7 | 218.2 | 167 | 71 | 68 | 18 | 89 | 186 | 2 | 0 | 0 | 2 | 24 | 11 | 3 | 3.74 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 64 | 24 | 24 | 7 | 13 | 5.55 | .339 | 1.49 | 10.0 | 3.4 | 7.0 | 121.2 | 135 | 75 | 75 | 10 | 46 | 94 | 0 | 0 | 0 | 0 | 10 | 6 | 7 | 3.81 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 100 | 0 | 4 | 2 | 2.03 | .237 | 0.87 | 4.5 | 3.3 | 10.2 | 93.1 | 47 | 21 | 21 | 3 | 34 | 105 | 0 | 2 | 0 | 0 | 0 | 6 | 9 | 2.45 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 98 | 72 | 0 | 6 | 3 | 1.33 | .214 | 0.80 | 4.8 | 2.4 | 10.9 | 81.0 | 43 | 12 | 12 | 4 | 22 | 98 | 0 | 51 | 4 | 0 | 0 | 1 | 2 | 2.07 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 82 | 49 | 0 | 4 | 1 | 1.15 | .258 | 1.04 | 7.3 | 2.1 | 10.1 | 47.0 | 38 | 9 | 6 | 3 | 11 | 53 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.28 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 63 | 52 | 0 | 0 | 1 | 0.69 | .209 | 0.79 | 4.4 | 2.8 | 7.2 | 39.0 | 19 | 4 | 3 | 2 | 12 | 31 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 3.00 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 57 | 37 | 0 | 3 | 2 | 3.38 | .301 | 1.27 | 6.0 | 5.4 | 7.5 | 48.0 | 32 | 18 | 18 | 2 | 29 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.75 |