| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 94 | 25 | 25 | 16 | 3 | 2.15 | .251 | 0.98 | 6.1 | 2.7 | 6.0 | 179.2 | 122 | 45 | 43 | 8 | 54 | 119 | 1 | 0 | 0 | 0 | 24 | 5 | 6 | 3.24 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 93 | 24 | 24 | 9 | 9 | 4.05 | .289 | 1.20 | 7.8 | 3.0 | 5.9 | 160.0 | 138 | 75 | 72 | 14 | 54 | 104 | 1 | 0 | 0 | 0 | 13 | 3 | 1 | 3.91 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 94 | 23 | 23 | 15 | 4 | 1.72 | .258 | 0.99 | 6.1 | 2.9 | 7.5 | 167.2 | 113 | 37 | 32 | 9 | 53 | 140 | 2 | 0 | 0 | 0 | 20 | 9 | 5 | 3.14 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 70 | 19 | 18 | 4 | 7 | 3.86 | .268 | 1.09 | 7.1 | 2.8 | 6.9 | 107.1 | 84 | 46 | 46 | 16 | 33 | 82 | 0 | 0 | 0 | 0 | 10 | 1 | 4 | 4.36 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 72 | 0 | 1 | 1 | 0.92 | .228 | 0.87 | 4.2 | 3.7 | 10.6 | 58.2 | 27 | 6 | 6 | 2 | 24 | 68 | 0 | 3 | 1 | 0 | 0 | 1 | 6 | 2.40 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 100 | 49 | 0 | 2 | 7 | 2.66 | .248 | 0.95 | 4.7 | 4.0 | 11.7 | 50.2 | 26 | 16 | 15 | 5 | 22 | 65 | 0 | 31 | 4 | 0 | 0 | 2 | 2 | 3.14 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 90 | 22 | 0 | 0 | 3 | 2.04 | .274 | 1.13 | 6.4 | 4.2 | 9.5 | 17.2 | 12 | 5 | 4 | 0 | 8 | 18 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.29 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 74 | 42 | 0 | 3 | 0 | 2.08 | .220 | 0.85 | 4.5 | 3.1 | 7.3 | 26.0 | 13 | 7 | 6 | 2 | 9 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.42 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 65 | 21 | 0 | 1 | 3 | 5.95 | .330 | 1.47 | 10.9 | 2.8 | 10.4 | 19.2 | 23 | 13 | 13 | 4 | 6 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.37 |