| SP | Glasnow, T.Glasnow, Tyler >> | 27 | 2021 | R | 99 | 35 | 35 | 15 | 12 | 2.60 | .269 | 1.10 | 6.4 | 3.5 | 9.6 | 239.0 | 170 | 71 | 69 | 12 | 92 | 255 | 2 | 0 | 0 | 1 | 27 | 2 | 14 | 2.70 |
| SP | Patino, L.Patino, Luis >> | 21 | 2021 | R | 55 | 34 | 34 | 5 | 9 | 3.26 | .275 | 1.13 | 7.4 | 2.8 | 7.9 | 160.0 | 131 | 59 | 58 | 12 | 49 | 140 | 1 | 0 | 0 | 1 | 3 | 2 | 10 | 3.18 |
| SP | McClanahan, S.McClanahan, Shane >> | 24 | 2021 | L | 47 | 25 | 23 | 5 | 12 | 5.30 | .326 | 1.43 | 10.0 | 2.9 | 9.8 | 120.2 | 133 | 73 | 71 | 17 | 39 | 131 | 0 | 0 | 0 | 0 | 4 | 3 | 8 | 3.71 |
| RP | McHugh, C.McHugh, Collin >> | 34 | 2021 | R | 89 | 86 | 0 | 15 | 5 | 2.49 | .267 | 1.06 | 7.2 | 2.3 | 9.6 | 170.0 | 136 | 51 | 47 | 15 | 44 | 181 | 0 | 0 | 3 | 0 | 0 | 6 | 7 | 2.90 |
| RP | Castillo, D.Castillo, Diego >> | 27 | 2021 | R | 91 | 86 | 0 | 5 | 1 | 3.14 | .270 | 1.09 | 6.9 | 3.0 | 8.7 | 114.2 | 87 | 43 | 40 | 14 | 38 | 110 | 0 | 0 | 3 | 0 | 0 | 2 | 2 | 3.72 |
| RP | Richards, T.Richards, Trevor >> | 28 | 2021 | R | 94 | 78 | 0 | 4 | 4 | 2.29 | .248 | 0.98 | 6.4 | 2.4 | 9.4 | 102.1 | 73 | 26 | 26 | 6 | 27 | 107 | 0 | 3 | 2 | 0 | 0 | 1 | 8 | 2.49 |
| RP | Thompson, R.Thompson, Ryan >> | 29 | 2021 | R | 83 | 51 | 0 | 5 | 1 | 2.49 | .240 | 0.93 | 6.3 | 2.1 | 9.3 | 61.1 | 43 | 17 | 17 | 6 | 14 | 63 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 2.95 |
| RP | Kittredge, A.Kittredge, Andrew >> | 31 | 2021 | R | 83 | 37 | 0 | 1 | 4 | 2.93 | .259 | 1.00 | 7.7 | 1.4 | 7.7 | 40.0 | 34 | 13 | 13 | 4 | 6 | 34 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Chargois, J.Chargois, J.T. >> | 30 | 2021 | R | 78 | 24 | 0 | 1 | 0 | 2.27 | .264 | 1.07 | 7.5 | 2.3 | 9.6 | 31.2 | 26 | 8 | 8 | 4 | 8 | 33 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.32 |