| SP | Rodon, C.Rodon, Carlos >> | 28 | 2021 | L | 97 | 11 | 11 | 6 | 1 | 2.30 | .265 | 1.04 | 7.1 | 2.3 | 8.6 | 70.1 | 55 | 19 | 18 | 6 | 18 | 67 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 3.10 |
| SP | Altrock, N.Altrock, Nick >> | 28 | 1904 | L | 50 | 35 | 35 | 18 | 11 | 3.62 | .296 | 1.24 | 8.5 | 2.7 | 4.6 | 243.2 | 230 | 111 | 98 | 19 | 73 | 124 | 9 | 0 | 0 | 1 | 22 | 4 | 9 | 3.95 |
| RP | Keuchel, D.Keuchel, Dallas >> | 32 | 2020 | L | 52 | 81 | 0 | 5 | 2 | 2.82 | .234 | 0.91 | 6.4 | 1.9 | 6.0 | 130.2 | 92 | 48 | 41 | 11 | 27 | 87 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Kahnle, T.Kahnle, Tommy >> | 27 | 2017 | R | 73 | 59 | 0 | 3 | 6 | 3.68 | .257 | 1.01 | 6.9 | 2.3 | 11.9 | 63.2 | 48 | 27 | 26 | 6 | 16 | 83 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 2.46 |
| RP | Marte, D.Marte, Damaso >> | 27 | 2002 | L | 68 | 33 | 0 | 4 | 1 | 1.65 | .222 | 0.86 | 6.2 | 1.7 | 8.4 | 32.2 | 22 | 6 | 6 | 2 | 6 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.50 |
| RP | Gossage, R.Gossage, Rich >> | 21 | 1972 | R | 16 | 32 | 0 | 1 | 2 | 2.20 | .259 | 1.05 | 5.5 | 4.0 | 5.7 | 41.0 | 25 | 10 | 10 | 3 | 18 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.00 |
| CL | Hendriks, L.Hendriks, Liam † >> | 32 | 2021 | R | 96 | 73 | 0 | 4 | 8 | 2.52 | .248 | 0.99 | 6.9 | 2.1 | 9.6 | 78.2 | 60 | 22 | 22 | 5 | 18 | 83 | 0 | 45 | 3 | 0 | 0 | 0 | 3 | 2.40 |