| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 26 | 26 | 6 | 14 | 4.72 | .333 | 1.48 | 8.4 | 5.0 | 8.4 | 156.1 | 146 | 96 | 82 | 24 | 86 | 145 | 0 | 0 | 0 | 0 | 11 | 2 | 4 | 4.83 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 25 | 25 | 8 | 10 | 4.18 | .322 | 1.41 | 8.6 | 4.1 | 7.8 | 170.0 | 162 | 87 | 79 | 17 | 77 | 148 | 4 | 0 | 0 | 2 | 12 | 3 | 5 | 3.97 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 25 | 25 | 9 | 11 | 5.00 | .314 | 1.34 | 9.3 | 2.8 | 5.0 | 169.1 | 175 | 101 | 94 | 24 | 52 | 94 | 6 | 0 | 0 | 2 | 10 | 6 | 7 | 4.76 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 79 | 25 | 25 | 3 | 16 | 6.68 | .364 | 1.69 | 11.4 | 3.8 | 8.9 | 134.2 | 170 | 110 | 100 | 23 | 57 | 133 | 0 | 0 | 0 | 0 | 6 | 4 | 5 | 4.61 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 24 | 24 | 7 | 12 | 5.79 | .358 | 1.65 | 9.5 | 5.3 | 5.4 | 150.2 | 159 | 108 | 97 | 21 | 89 | 90 | 3 | 0 | 0 | 1 | 9 | 4 | 6 | 5.48 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 64 | 0 | 3 | 3 | 4.50 | .281 | 1.15 | 8.4 | 1.9 | 9.2 | 88.0 | 82 | 50 | 44 | 12 | 19 | 90 | 0 | 3 | 7 | 0 | 0 | 2 | 0 | 3.44 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 61 | 0 | 4 | 3 | 3.84 | .310 | 1.33 | 8.3 | 3.7 | 7.8 | 75.0 | 69 | 35 | 32 | 7 | 31 | 65 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 3.76 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 56 | 0 | 5 | 3 | 3.20 | .260 | 1.05 | 6.8 | 2.7 | 7.5 | 70.1 | 53 | 25 | 25 | 12 | 21 | 58 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 4.47 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 61 | 24 | 0 | 2 | 1 | 3.34 | .331 | 1.48 | 7.4 | 6.2 | 4.0 | 29.2 | 24 | 13 | 11 | 1 | 20 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.62 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 10 | 0 | 1 | 0 | 5.28 | .333 | 1.43 | 7.2 | 6.0 | 7.2 | 15.1 | 12 | 9 | 9 | 2 | 10 | 12 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.33 |