| SP | Scherzer, M.Scherzer, Max # >> | 37 | 2021 | R | 97 | 32 | 32 | 11 | 16 | 4.84 | .321 | 1.40 | 9.2 | 3.4 | 8.4 | 189.2 | 194 | 104 | 102 | 23 | 72 | 176 | 0 | 0 | 0 | 0 | 15 | 3 | 0 | 3.91 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 87 | 31 | 31 | 17 | 8 | 3.74 | .291 | 1.21 | 7.1 | 3.7 | 8.6 | 248.0 | 197 | 105 | 103 | 18 | 103 | 238 | 15 | 0 | 0 | 5 | 16 | 6 | 5 | 3.34 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 78 | 30 | 30 | 0 | 4 | 3.46 | .304 | 1.28 | 8.9 | 2.7 | 5.8 | 78.0 | 77 | 33 | 30 | 5 | 23 | 50 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.51 |
| SP | Perez, P.Perez, Pascual † >> | 31 | 1988 | R | 73 | 30 | 30 | 15 | 10 | 4.17 | .313 | 1.32 | 8.2 | 3.7 | 4.7 | 215.2 | 197 | 106 | 100 | 18 | 88 | 113 | 4 | 0 | 0 | 3 | 17 | 10 | 1 | 4.40 |
| SP | Martinez, D.Martinez, Dennis # >> | 37 | 1992 | R | 48 | 30 | 30 | 10 | 12 | 4.91 | .334 | 1.49 | 9.3 | 4.2 | 5.3 | 196.0 | 202 | 121 | 107 | 26 | 91 | 116 | 6 | 0 | 0 | 2 | 14 | 2 | 6 | 4.96 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 77 | 0 | 5 | 4 | 2.80 | .254 | 0.99 | 7.2 | 1.7 | 9.3 | 106.0 | 85 | 39 | 33 | 6 | 20 | 110 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 2.31 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 85 | 84 | 0 | 5 | 7 | 3.89 | .303 | 1.29 | 7.8 | 3.8 | 5.3 | 120.1 | 104 | 57 | 52 | 16 | 51 | 70 | 0 | 7 | 6 | 0 | 0 | 2 | 1 | 4.89 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 75 | 58 | 0 | 1 | 3 | 4.36 | .307 | 1.28 | 6.9 | 4.6 | 8.4 | 64.0 | 49 | 31 | 31 | 4 | 33 | 60 | 0 | 6 | 6 | 0 | 0 | 3 | 2 | 3.63 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 73 | 51 | 0 | 5 | 5 | 2.54 | .312 | 1.36 | 7.8 | 4.5 | 8.0 | 60.1 | 52 | 19 | 17 | 0 | 30 | 53 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 2.73 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 59 | 30 | 0 | 3 | 5 | 4.85 | .305 | 1.25 | 8.4 | 3.1 | 10.9 | 29.2 | 27 | 18 | 16 | 4 | 10 | 35 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.62 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 57 | 24 | 0 | 0 | 3 | 4.84 | .391 | 1.88 | 11.5 | 5.7 | 9.8 | 22.1 | 28 | 12 | 12 | 2 | 14 | 24 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 47 | 65 | 0 | 1 | 3 | 3.71 | .335 | 1.49 | 10.3 | 3.3 | 5.7 | 43.2 | 49 | 20 | 18 | 6 | 16 | 27 | 0 | 7 | 1 | 0 | 0 | 1 | 2 | 4.74 |