| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 97 | 4 | 4 | 1 | 2 | 3.38 | .280 | 1.17 | 7.5 | 3.0 | 8.6 | 24.0 | 20 | 9 | 9 | 0 | 8 | 23 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2.08 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 87 | 3 | 3 | 3 | 0 | 2.73 | .248 | 0.87 | 5.9 | 2.1 | 8.0 | 26.1 | 17 | 8 | 8 | 2 | 6 | 23 | 2 | 0 | 0 | 0 | 2 | 3 | 0 | 3.27 |
| SP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 78 | 3 | 3 | 0 | 1 | 3.12 | .257 | 1.04 | 7.9 | 2.3 | 6.8 | 8.2 | 7 | 3 | 3 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.25 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 73 | 3 | 3 | 2 | 0 | 2.78 | .327 | 1.41 | 9.0 | 4.1 | 4.5 | 22.2 | 22 | 9 | 7 | 1 | 10 | 11 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.09 |
| SP | Martinez, D.Martinez, Dennis >> | 37 | 1992 | R | 48 | 3 | 3 | 1 | 2 | 11.57 | .408 | 2.07 | 12.9 | 5.8 | 3.2 | 14.0 | 20 | 19 | 18 | 5 | 9 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.86 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 8 | 0 | 1 | 1 | 4.22 | .256 | 1.03 | 8.1 | 1.8 | 14.4 | 10.2 | 9 | 5 | 5 | 2 | 2 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 85 | 9 | 0 | 0 | 1 | 2.20 | .246 | 0.98 | 5.6 | 3.4 | 5.1 | 16.1 | 10 | 5 | 4 | 1 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.81 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 75 | 5 | 0 | 0 | 0 | 3.86 | .300 | 1.07 | 4.5 | 6.8 | 6.8 | 4.2 | 2 | 2 | 2 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.75 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 73 | 4 | 0 | 1 | 0 | 0.00 | .143 | 0.50 | 2.3 | 2.3 | 13.5 | 4.0 | 1 | 0 | 0 | 0 | 1 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0.75 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 59 | 2 | 0 | 0 | 0 | 5.40 | .167 | 0.60 | 9.0 | 0.0 | 9.0 | 1.2 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 57 | 2 | 0 | 0 | 0 | 2.70 | .286 | 1.20 | 9.0 | 3.0 | 9.0 | 3.1 | 3 | 1 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 47 | 7 | 0 | 0 | 0 | 2.70 | .200 | 0.75 | 7.5 | 0.0 | 3.0 | 6.2 | 5 | 2 | 2 | 1 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.50 |