| SP | Jimenez, U.Jimenez, Ubaldo >> | 26 | 2010 | R | 28 | 33 | 33 | 11 | 13 | 4.61 | .312 | 1.33 | 8.3 | 3.7 | 6.1 | 214.2 | 197 | 115 | 110 | 30 | 89 | 146 | 3 | 0 | 0 | 2 | 15 | 6 | 9 | 4.79 |
| SP | Marquez, G.Marquez, German >> | 23 | 2018 | R | 19 | 32 | 32 | 12 | 10 | 4.76 | .322 | 1.38 | 8.8 | 3.7 | 8.6 | 191.0 | 186 | 109 | 101 | 21 | 78 | 183 | 1 | 0 | 0 | 0 | 13 | 8 | 9 | 3.86 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 18 | 32 | 32 | 6 | 14 | 5.80 | .354 | 1.63 | 9.1 | 5.6 | 8.0 | 149.0 | 151 | 97 | 96 | 24 | 92 | 132 | 0 | 0 | 0 | 0 | 3 | 2 | 5 | 5.21 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 17 | 31 | 31 | 8 | 14 | 5.67 | .309 | 1.32 | 9.5 | 2.5 | 6.9 | 160.1 | 168 | 103 | 101 | 34 | 44 | 123 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 5.11 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 61 | 75 | 0 | 2 | 4 | 3.79 | .323 | 1.43 | 7.1 | 5.8 | 9.6 | 97.1 | 76 | 47 | 41 | 9 | 63 | 103 | 0 | 3 | 6 | 0 | 0 | 0 | 14 | 4.03 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 56 | 78 | 0 | 5 | 5 | 4.45 | .323 | 1.42 | 9.6 | 3.2 | 9.7 | 93.0 | 99 | 47 | 46 | 15 | 33 | 100 | 0 | 7 | 6 | 0 | 0 | 1 | 4 | 4.04 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 50 | 73 | 0 | 5 | 7 | 4.52 | .297 | 1.25 | 8.6 | 2.8 | 7.7 | 83.2 | 79 | 43 | 42 | 12 | 26 | 71 | 0 | 9 | 6 | 0 | 0 | 1 | 0 | 4.14 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 53 | 46 | 0 | 3 | 2 | 2.94 | .293 | 1.22 | 7.7 | 3.3 | 9.2 | 49.0 | 42 | 16 | 16 | 6 | 18 | 50 | 0 | 8 | 2 | 0 | 0 | 1 | 4 | 3.71 |
| RP | DeJean, M.DeJean, Mike >> | 35 | 2005 | R | 25 | 30 | 0 | 1 | 0 | 5.73 | .313 | 1.36 | 8.5 | 3.8 | 6.8 | 33.0 | 31 | 21 | 21 | 5 | 14 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4.73 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 29 | 2010 | L | 13 | 38 | 0 | 13 | 2 | 4.69 | .313 | 1.35 | 7.6 | 4.6 | 5.7 | 144.0 | 121 | 77 | 75 | 21 | 74 | 91 | 0 | 1 | 0 | 0 | 0 | 2 | 8 | 5.22 |