| SP | Kershaw, C.Kershaw, Clayton $$ >> | 28 | 2016 | L | 99 | 36 | 36 | 18 | 9 | 3.38 | .294 | 1.21 | 8.6 | 2.3 | 8.7 | 260.2 | 248 | 106 | 98 | 21 | 67 | 252 | 4 | 0 | 0 | 1 | 22 | 11 | 3 | 3.01 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 35 | 35 | 14 | 10 | 3.38 | .310 | 1.32 | 7.1 | 4.9 | 8.1 | 228.2 | 179 | 99 | 86 | 19 | 123 | 205 | 1 | 0 | 0 | 1 | 23 | 6 | 5 | 3.98 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 34 | 34 | 10 | 16 | 6.91 | .333 | 1.48 | 10.1 | 3.3 | 5.3 | 165.1 | 185 | 137 | 127 | 38 | 60 | 97 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 5.96 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 31 | 31 | 13 | 13 | 5.72 | .333 | 1.48 | 9.8 | 3.5 | 6.0 | 190.1 | 207 | 130 | 121 | 36 | 74 | 126 | 2 | 0 | 0 | 0 | 13 | 4 | 4 | 5.37 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 63 | 0 | 6 | 3 | 2.14 | .243 | 0.95 | 5.9 | 2.7 | 11.3 | 67.1 | 44 | 16 | 16 | 8 | 20 | 84 | 0 | 41 | 2 | 0 | 0 | 1 | 0 | 2.99 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 63 | 0 | 0 | 6 | 3.80 | .285 | 1.17 | 8.9 | 1.6 | 8.2 | 71.0 | 70 | 35 | 30 | 8 | 13 | 65 | 0 | 6 | 8 | 0 | 0 | 2 | 2 | 3.27 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 79 | 0 | 3 | 4 | 4.52 | .315 | 1.35 | 7.9 | 4.3 | 9.7 | 87.2 | 76 | 49 | 44 | 8 | 42 | 94 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.59 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 58 | 0 | 7 | 2 | 4.11 | .273 | 1.13 | 6.9 | 3.2 | 9.0 | 61.1 | 47 | 29 | 28 | 7 | 22 | 61 | 0 | 1 | 2 | 0 | 0 | 0 | 8 | 3.57 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 45 | 0 | 6 | 0 | 4.68 | .309 | 1.32 | 8.3 | 3.6 | 8.1 | 50.0 | 46 | 28 | 26 | 7 | 20 | 45 | 0 | 1 | 0 | 0 | 0 | 1 | 6 | 4.28 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 2 | 0 | 0 | 1 | 8.31 | .316 | 1.38 | 13.5 | 0.0 | 11.3 | 4.1 | 6 | 4 | 4 | 1 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.75 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 8 | 0 | 0 | 0 | 4.80 | .348 | 1.60 | 10.8 | 3.6 | 4.8 | 15.0 | 18 | 8 | 8 | 2 | 6 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.87 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 23 | 0 | 1 | 1 | 3.16 | .275 | 1.13 | 7.4 | 2.8 | 5.5 | 105.1 | 86 | 43 | 37 | 8 | 33 | 64 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.74 |