| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 34 | 34 | 10 | 18 | 5.58 | .341 | 1.50 | 9.0 | 4.5 | 8.3 | 193.2 | 194 | 127 | 120 | 29 | 97 | 179 | 0 | 0 | 0 | 0 | 13 | 9 | 3 | 4.75 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 33 | 33 | 17 | 11 | 3.89 | .293 | 1.21 | 8.8 | 2.1 | 5.5 | 213.0 | 208 | 106 | 92 | 26 | 49 | 131 | 7 | 0 | 0 | 2 | 19 | 8 | 7 | 4.16 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 33 | 33 | 7 | 17 | 7.08 | .380 | 1.82 | 12.6 | 3.9 | 8.1 | 157.2 | 219 | 138 | 124 | 27 | 68 | 141 | 1 | 0 | 0 | 0 | 6 | 3 | 10 | 4.80 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 32 | 32 | 11 | 14 | 5.10 | .336 | 1.51 | 10.0 | 3.6 | 6.4 | 180.0 | 199 | 112 | 102 | 29 | 72 | 128 | 3 | 0 | 0 | 1 | 15 | 2 | 2 | 4.91 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 78 | 0 | 4 | 3 | 5.78 | .315 | 1.34 | 9.7 | 2.4 | 9.1 | 85.2 | 92 | 59 | 55 | 16 | 23 | 86 | 0 | 4 | 2 | 0 | 0 | 3 | 1 | 4.34 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 69 | 0 | 2 | 2 | 3.43 | .298 | 1.26 | 7.9 | 3.4 | 9.6 | 76.0 | 67 | 36 | 29 | 8 | 29 | 81 | 0 | 3 | 4 | 0 | 0 | 1 | 2 | 3.42 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 82 | 55 | 0 | 1 | 0 | 4.57 | .317 | 1.39 | 8.0 | 4.6 | 8.6 | 61.0 | 54 | 33 | 31 | 11 | 31 | 58 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.97 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 45 | 0 | 1 | 2 | 3.50 | .286 | 1.19 | 8.3 | 2.3 | 7.8 | 54.0 | 50 | 21 | 21 | 6 | 14 | 47 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.54 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 39 | 0 | 1 | 1 | 3.69 | .320 | 1.41 | 6.9 | 5.8 | 11.1 | 39.0 | 30 | 17 | 16 | 1 | 25 | 48 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2.79 |