| SP | Koufax, S.Koufax, Sandy # $$ >> | 30 | 1965 | L | 98 | 22 | 22 | 5 | 11 | 5.21 | .318 | 1.36 | 9.6 | 2.6 | 9.0 | 133.0 | 142 | 79 | 77 | 22 | 39 | 133 | 3 | 0 | 0 | 0 | 9 | 5 | 2 | 4.14 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 21 | 21 | 10 | 8 | 3.49 | .276 | 1.10 | 7.3 | 2.6 | 3.9 | 136.2 | 110 | 56 | 53 | 10 | 40 | 59 | 4 | 0 | 0 | 3 | 12 | 6 | 4 | 4.10 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 21 | 21 | 10 | 6 | 3.98 | .298 | 1.27 | 8.3 | 3.1 | 5.5 | 138.0 | 128 | 65 | 61 | 11 | 47 | 84 | 3 | 0 | 0 | 2 | 12 | 1 | 6 | 3.86 |
| SP | Ryan, N.Ryan, Nolan $$ >> | 44 | 1991 | R | 73 | 20 | 20 | 9 | 4 | 4.47 | .315 | 1.38 | 7.8 | 4.7 | 8.0 | 114.2 | 99 | 58 | 57 | 8 | 59 | 101 | 0 | 0 | 0 | 0 | 11 | 0 | 3 | 3.69 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 20 | 17 | 8 | 7 | 4.37 | .334 | 1.48 | 8.5 | 4.9 | 3.7 | 123.2 | 116 | 68 | 60 | 7 | 67 | 51 | 1 | 0 | 0 | 0 | 10 | 3 | 1 | 4.62 |
| CL | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 40 | 0 | 0 | 3 | 3.27 | .309 | 1.32 | 8.4 | 3.5 | 7.8 | 44.0 | 41 | 16 | 16 | 5 | 17 | 38 | 0 | 22 | 6 | 0 | 0 | 1 | 1 | 3.98 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 56 | 0 | 3 | 0 | 3.52 | .299 | 1.26 | 8.2 | 3.1 | 9.0 | 46.0 | 42 | 18 | 18 | 3 | 16 | 46 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 2.96 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 50 | 0 | 0 | 1 | 3.17 | .247 | 0.96 | 5.2 | 3.5 | 9.3 | 54.0 | 31 | 19 | 19 | 5 | 21 | 56 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.35 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 38 | 0 | 3 | 4 | 5.24 | .348 | 1.60 | 7.7 | 6.9 | 8.5 | 34.1 | 29 | 21 | 20 | 3 | 26 | 32 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.56 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 22 | 0 | 1 | 4 | 3.71 | .400 | 2.00 | 15.9 | 2.1 | 8.5 | 17.0 | 30 | 12 | 7 | 1 | 4 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.59 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 12 | 0 | 1 | 1 | 4.50 | .321 | 1.42 | 10.5 | 2.3 | 4.5 | 12.0 | 14 | 6 | 6 | 1 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.83 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 17 | 3 | 2 | 3 | 4.27 | .331 | 1.44 | 7.8 | 5.3 | 4.2 | 65.1 | 56 | 31 | 31 | 3 | 38 | 30 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 4.57 |