| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 39 | 39 | 16 | 9 | 3.20 | .251 | 0.99 | 6.8 | 2.1 | 9.8 | 267.1 | 201 | 98 | 95 | 33 | 63 | 292 | 2 | 0 | 0 | 0 | 27 | 5 | 0 | 3.18 |
| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 36 | 36 | 20 | 9 | 3.78 | .289 | 1.20 | 8.2 | 2.6 | 5.4 | 269.1 | 244 | 115 | 113 | 37 | 78 | 160 | 7 | 0 | 0 | 1 | 22 | 7 | 4 | 4.55 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 35 | 35 | 12 | 18 | 5.44 | .334 | 1.49 | 10.0 | 3.4 | 8.1 | 216.2 | 241 | 137 | 131 | 34 | 81 | 194 | 1 | 0 | 0 | 0 | 14 | 4 | 6 | 4.43 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 85 | 35 | 35 | 12 | 9 | 3.61 | .262 | 1.06 | 7.2 | 2.4 | 8.0 | 229.1 | 182 | 101 | 92 | 31 | 60 | 203 | 1 | 0 | 0 | 0 | 21 | 2 | 3 | 3.80 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 99 | 0 | 8 | 4 | 2.50 | .237 | 0.87 | 5.7 | 2.2 | 9.4 | 129.2 | 81 | 38 | 36 | 9 | 32 | 135 | 0 | 11 | 3 | 0 | 0 | 8 | 0 | 2.74 |