| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 35 | 35 | 19 | 8 | 2.54 | .268 | 1.08 | 6.8 | 2.9 | 9.9 | 230.0 | 173 | 70 | 65 | 18 | 75 | 252 | 1 | 0 | 0 | 1 | 29 | 5 | 0 | 2.87 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 33 | 33 | 18 | 9 | 3.93 | .273 | 1.12 | 7.9 | 2.2 | 9.1 | 240.1 | 211 | 106 | 105 | 36 | 58 | 242 | 8 | 0 | 0 | 1 | 17 | 2 | 2 | 3.68 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 33 | 33 | 11 | 7 | 4.68 | .346 | 1.54 | 8.9 | 5.0 | 8.1 | 196.1 | 194 | 113 | 102 | 16 | 109 | 176 | 0 | 0 | 0 | 0 | 17 | 8 | 3 | 4.06 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 31 | 31 | 14 | 14 | 4.77 | .305 | 1.28 | 9.1 | 2.5 | 7.3 | 209.1 | 211 | 119 | 111 | 41 | 57 | 169 | 8 | 0 | 0 | 1 | 12 | 7 | 8 | 4.85 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 84 | 0 | 4 | 8 | 4.26 | .276 | 1.12 | 7.6 | 2.5 | 8.0 | 105.2 | 89 | 56 | 50 | 16 | 29 | 93 | 0 | 12 | 5 | 0 | 0 | 3 | 2 | 4.12 |
| RP | Papelbon, J.Papelbon, Jonathan # >> | 27 | 2007 | R | 92 | 71 | 0 | 5 | 1 | 4.57 | .291 | 1.23 | 8.5 | 2.7 | 8.9 | 84.2 | 79 | 43 | 43 | 15 | 25 | 83 | 0 | 10 | 3 | 0 | 0 | 0 | 0 | 4.24 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 50 | 0 | 5 | 3 | 2.52 | .260 | 1.05 | 8.0 | 1.7 | 8.7 | 60.2 | 53 | 17 | 17 | 4 | 11 | 58 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 2.48 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 38 | 0 | 5 | 2 | 2.93 | .298 | 1.20 | 7.2 | 3.6 | 7.7 | 40.0 | 32 | 14 | 13 | 3 | 16 | 34 | 0 | 4 | 1 | 0 | 0 | 3 | 2 | 3.70 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 22 | 0 | 3 | 0 | 2.67 | .236 | 0.89 | 5.7 | 2.3 | 8.0 | 27.0 | 17 | 8 | 8 | 4 | 7 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.04 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 34 | 0 | 1 | 0 | 3.70 | .311 | 1.34 | 8.8 | 3.4 | 7.3 | 48.2 | 47 | 22 | 20 | 5 | 18 | 39 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.92 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 8 | 0 | 0 | 1 | 5.11 | .302 | 1.22 | 7.5 | 3.8 | 7.5 | 12.1 | 10 | 7 | 7 | 1 | 5 | 10 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.92 |