| SP | Martinez, P.Martinez, Pedro † $$ >> | 29 | 2000 | R | 100 | 38 | 38 | 16 | 15 | 2.91 | .276 | 1.11 | 7.5 | 2.5 | 9.0 | 275.2 | 230 | 98 | 89 | 27 | 76 | 274 | 7 | 0 | 0 | 3 | 25 | 9 | 5 | 3.21 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 20 | 20 | 5 | 10 | 3.61 | .306 | 1.32 | 7.2 | 4.6 | 3.8 | 132.0 | 106 | 63 | 53 | 11 | 68 | 56 | 1 | 0 | 0 | 0 | 14 | 1 | 0 | 4.80 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 34 | 34 | 17 | 10 | 3.64 | .292 | 1.22 | 8.1 | 2.8 | 4.3 | 237.1 | 214 | 103 | 96 | 31 | 75 | 114 | 12 | 0 | 0 | 0 | 21 | 4 | 3 | 4.74 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 28 | 16 | 4 | 6 | 4.58 | .309 | 1.32 | 8.6 | 3.3 | 5.9 | 139.2 | 133 | 74 | 71 | 19 | 51 | 91 | 3 | 0 | 0 | 0 | 5 | 3 | 2 | 4.63 |
| CL | Feliz, N.Feliz, Neftali † $$ >> | 21 | 2009 | R | 97 | 61 | 0 | 6 | 11 | 3.47 | .284 | 1.16 | 5.8 | 4.6 | 10.0 | 62.1 | 40 | 24 | 24 | 7 | 32 | 69 | 0 | 39 | 3 | 0 | 0 | 2 | 0 | 3.89 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 79 | 0 | 7 | 3 | 3.32 | .272 | 1.12 | 5.7 | 4.5 | 10.0 | 62.1 | 39 | 23 | 23 | 6 | 31 | 69 | 0 | 0 | 2 | 0 | 0 | 0 | 5 | 3.53 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 30 | 0 | 5 | 1 | 4.02 | .299 | 1.28 | 8.1 | 3.5 | 6.4 | 31.1 | 28 | 14 | 14 | 4 | 12 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.42 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 18 | 0 | 0 | 1 | 1.89 | .260 | 1.05 | 5.2 | 4.3 | 6.6 | 19.0 | 11 | 4 | 4 | 1 | 9 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.63 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 15 | 0 | 0 | 0 | 4.60 | .356 | 1.60 | 9.6 | 5.4 | 8.4 | 15.2 | 16 | 8 | 8 | 2 | 9 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.87 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 9 | 0 | 0 | 0 | 3.12 | .333 | 1.38 | 7.9 | 5.6 | 6.8 | 8.2 | 7 | 3 | 3 | 1 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.38 |