| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 22 | 22 | 8 | 5 | 3.02 | .290 | 1.21 | 7.8 | 3.1 | 8.2 | 158.0 | 137 | 54 | 53 | 12 | 54 | 144 | 2 | 0 | 0 | 0 | 16 | 3 | 1 | 3.25 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 21 | 21 | 3 | 10 | 6.16 | .346 | 1.58 | 10.1 | 4.1 | 8.3 | 114.0 | 128 | 81 | 78 | 18 | 52 | 105 | 0 | 0 | 0 | 0 | 9 | 1 | 4 | 4.61 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 22 | 21 | 8 | 7 | 4.98 | .332 | 1.47 | 10.0 | 3.3 | 9.1 | 119.1 | 132 | 66 | 66 | 18 | 43 | 120 | 2 | 0 | 0 | 0 | 9 | 3 | 2 | 4.11 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 21 | 21 | 7 | 9 | 4.91 | .320 | 1.39 | 9.3 | 3.3 | 6.0 | 124.2 | 128 | 71 | 68 | 13 | 45 | 83 | 3 | 0 | 0 | 0 | 8 | 3 | 3 | 4.19 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 71 | 20 | 20 | 7 | 7 | 4.84 | .325 | 1.43 | 9.9 | 3.0 | 4.6 | 122.2 | 134 | 69 | 66 | 14 | 41 | 63 | 2 | 0 | 0 | 1 | 9 | 2 | 2 | 4.52 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 56 | 0 | 6 | 7 | 4.05 | .331 | 1.44 | 8.0 | 5.0 | 7.6 | 66.2 | 59 | 32 | 30 | 5 | 37 | 56 | 0 | 17 | 5 | 0 | 0 | 3 | 0 | 4.11 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 57 | 0 | 1 | 2 | 4.48 | .298 | 1.26 | 6.8 | 4.7 | 7.7 | 60.1 | 45 | 31 | 30 | 10 | 31 | 51 | 0 | 3 | 4 | 0 | 0 | 1 | 1 | 5.07 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 37 | 0 | 2 | 3 | 2.41 | .230 | 0.88 | 6.6 | 1.4 | 6.9 | 52.1 | 38 | 14 | 14 | 6 | 8 | 40 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.48 |