| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 80 | 5 | 5 | 3 | 1 | 4.88 | .333 | 1.47 | 11.0 | 2.3 | 8.4 | 31.1 | 38 | 17 | 17 | 5 | 8 | 29 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 4.10 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 73 | 4 | 4 | 3 | 1 | 2.83 | .259 | 1.01 | 7.1 | 2.3 | 6.4 | 28.2 | 22 | 9 | 9 | 3 | 7 | 20 | 2 | 0 | 0 | 0 | 3 | 1 | 0 | 3.82 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 63 | 4 | 4 | 3 | 1 | 1.19 | .260 | 1.05 | 7.5 | 2.1 | 8.1 | 30.1 | 25 | 6 | 4 | 2 | 7 | 27 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2.77 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 58 | 4 | 4 | 2 | 2 | 5.56 | .327 | 1.37 | 10.6 | 2.0 | 11.5 | 22.2 | 26 | 14 | 14 | 2 | 5 | 28 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 2.59 |
| SP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 71 | 4 | 4 | 0 | 1 | 3.65 | .260 | 1.05 | 9.0 | 0.8 | 6.0 | 12.1 | 12 | 5 | 5 | 1 | 1 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 63 | 12 | 0 | 0 | 0 | 3.21 | .354 | 1.57 | 10.9 | 3.2 | 4.5 | 14.0 | 17 | 8 | 5 | 3 | 5 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6.07 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 57 | 7 | 0 | 1 | 0 | 0.00 | .138 | 0.48 | 3.4 | 1.1 | 13.5 | 8.1 | 3 | 3 | 0 | 0 | 1 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.38 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 48 | 10 | 0 | 1 | 0 | 6.00 | .325 | 1.44 | 10.0 | 3.0 | 6.0 | 9.0 | 10 | 6 | 6 | 2 | 3 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.56 |
| RP | Suggs, G.Suggs, George >> | 27 | 1909 | R | 27 | 8 | 0 | 0 | 0 | 0.90 | .268 | 1.10 | 7.2 | 2.7 | 7.2 | 10.0 | 8 | 1 | 1 | 0 | 3 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.30 |
| SP | Willett, E.Willett, Ed >> | 25 | 1909 | R | 26 | 1 | 0 | 0 | 0 | 9.00 | .400 | 2.00 | 13.5 | 4.5 | 0.0 | 2.0 | 3 | 2 | 2 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| CL | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 73 | 10 | 0 | 0 | 0 | 0.00 | .132 | 0.45 | 0.0 | 4.1 | 8.2 | 11.0 | 0 | 0 | 0 | 0 | 5 | 10 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 2.55 |