| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 98 | 36 | 36 | 10 | 18 | 5.57 | .327 | 1.43 | 10.0 | 3.0 | 9.2 | 198.2 | 220 | 128 | 123 | 33 | 65 | 202 | 0 | 0 | 0 | 0 | 11 | 5 | 0 | 4.19 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 88 | 35 | 35 | 19 | 10 | 4.08 | .276 | 1.13 | 7.6 | 2.6 | 8.7 | 264.2 | 223 | 126 | 120 | 41 | 75 | 255 | 17 | 0 | 0 | 4 | 17 | 4 | 1 | 3.98 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 75 | 35 | 35 | 10 | 18 | 6.67 | .346 | 1.56 | 10.7 | 3.4 | 6.0 | 195.2 | 232 | 155 | 145 | 47 | 73 | 129 | 2 | 0 | 0 | 1 | 10 | 5 | 11 | 6.01 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 32 | 32 | 32 | 10 | 13 | 6.39 | .347 | 1.56 | 10.3 | 3.7 | 8.8 | 163.1 | 187 | 117 | 116 | 38 | 67 | 160 | 0 | 0 | 0 | 0 | 15 | 6 | 2 | 5.41 |
| SP | Rogers, S.Rogers, Steve >> | 24 | 1973 | R | 28 | 25 | 24 | 6 | 12 | 4.38 | .302 | 1.26 | 7.7 | 3.6 | 5.3 | 172.2 | 148 | 96 | 84 | 31 | 69 | 101 | 7 | 0 | 0 | 3 | 12 | 7 | 8 | 5.49 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 78 | 0 | 6 | 3 | 1.73 | .245 | 0.95 | 6.4 | 2.1 | 11.5 | 109.0 | 78 | 26 | 21 | 6 | 26 | 139 | 0 | 2 | 4 | 0 | 0 | 2 | 3 | 1.94 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 86 | 66 | 0 | 9 | 5 | 2.40 | .230 | 0.86 | 5.4 | 2.3 | 5.8 | 105.0 | 63 | 28 | 28 | 8 | 27 | 68 | 0 | 13 | 1 | 0 | 0 | 4 | 1 | 3.58 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 68 | 40 | 0 | 1 | 1 | 2.56 | .228 | 0.87 | 5.0 | 2.9 | 9.6 | 56.1 | 31 | 16 | 16 | 4 | 18 | 60 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 2.80 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 63 | 28 | 0 | 5 | 1 | 1.42 | .286 | 1.14 | 7.3 | 3.2 | 9.3 | 31.2 | 25 | 5 | 5 | 4 | 11 | 32 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 3.87 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 57 | 14 | 0 | 1 | 1 | 7.11 | .321 | 1.34 | 8.3 | 4.5 | 9.0 | 12.2 | 11 | 10 | 10 | 1 | 6 | 12 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.83 |
| SP | Martinez, D.Martinez, Dennis >> | 37 | 1992 | R | 22 | 23 | 0 | 2 | 1 | 5.16 | .318 | 1.37 | 9.5 | 2.9 | 5.9 | 120.1 | 127 | 75 | 69 | 19 | 38 | 79 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.77 |