| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 85 | 36 | 36 | 11 | 17 | 3.89 | .277 | 1.13 | 7.8 | 2.5 | 9.1 | 268.2 | 231 | 117 | 116 | 40 | 73 | 272 | 8 | 0 | 0 | 1 | 18 | 5 | 2 | 3.78 |
| SP | Greinke, Z.Greinke, Zack >> | 36 | 2019 | R | 57 | 34 | 34 | 6 | 20 | 5.21 | .309 | 1.30 | 9.2 | 2.6 | 7.4 | 217.2 | 222 | 131 | 126 | 45 | 62 | 178 | 2 | 0 | 0 | 0 | 14 | 8 | 4 | 5.02 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 45 | 33 | 33 | 5 | 25 | 6.24 | .301 | 1.29 | 9.5 | 2.1 | 8.5 | 207.2 | 218 | 145 | 144 | 60 | 49 | 195 | 7 | 0 | 0 | 0 | 8 | 1 | 3 | 5.61 |
| RP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 44 | 93 | 0 | 5 | 7 | 3.72 | .269 | 1.09 | 7.3 | 2.5 | 6.9 | 164.1 | 133 | 69 | 68 | 20 | 46 | 125 | 0 | 22 | 6 | 0 | 0 | 2 | 3 | 3.94 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 40 | 51 | 0 | 4 | 3 | 2.45 | .254 | 1.02 | 6.4 | 2.9 | 10.1 | 58.2 | 41 | 16 | 16 | 4 | 19 | 65 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 2.64 |
| RP | Ramirez, N.Ramirez, Noe >> | 31 | 2021 | R | 36 | 29 | 0 | 2 | 2 | 3.73 | .329 | 1.47 | 8.1 | 5.2 | 5.8 | 31.1 | 28 | 13 | 13 | 5 | 18 | 20 | 0 | 4 | 3 | 0 | 0 | 0 | 2 | 5.55 |
| RP | Ziegler, B.Ziegler, Brad >> | 36 | 2015 | R | 3 | 16 | 0 | 1 | 1 | 2.79 | .275 | 1.09 | 7.1 | 2.8 | 5.2 | 19.1 | 15 | 6 | 6 | 4 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.68 |
| RP | Ginkel, K.Ginkel, Kevin >> | 29 | 2023 | R | 14 | 18 | 0 | 0 | 1 | 0.46 | .244 | 0.97 | 3.3 | 5.7 | 10.4 | 19.2 | 7 | 4 | 1 | 0 | 12 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.58 |
| SP | Corbin, P.Corbin, Patrick >> | 28 | 2018 | L | 17 | 14 | 0 | 2 | 0 | 5.71 | .329 | 1.42 | 9.8 | 3.1 | 9.3 | 64.2 | 70 | 41 | 41 | 13 | 22 | 66 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.75 |