| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 97 | 38 | 38 | 21 | 13 | 3.66 | .276 | 1.12 | 7.7 | 2.4 | 9.1 | 272.2 | 232 | 134 | 111 | 33 | 74 | 275 | 8 | 0 | 0 | 2 | 26 | 6 | 1 | 3.44 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 88 | 37 | 37 | 13 | 12 | 3.99 | .302 | 1.27 | 8.9 | 2.6 | 5.6 | 257.1 | 253 | 136 | 114 | 27 | 74 | 161 | 6 | 0 | 0 | 2 | 19 | 7 | 6 | 4.06 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 75 | 35 | 35 | 14 | 16 | 5.29 | .308 | 1.30 | 8.7 | 3.0 | 5.7 | 235.0 | 228 | 155 | 138 | 47 | 78 | 150 | 11 | 0 | 0 | 2 | 14 | 8 | 8 | 5.42 |
| SP | Alexander, P.Alexander, Pete >> | 32 | 1919 | R | 60 | 34 | 34 | 11 | 15 | 5.35 | .321 | 1.39 | 10.4 | 2.1 | 5.6 | 235.1 | 272 | 162 | 140 | 51 | 56 | 145 | 12 | 0 | 0 | 1 | 11 | 5 | 4 | 5.37 |
| SP | Corcoran, L.Corcoran, Larry >> | 21 | 1880 | R | 60 | 25 | 25 | 10 | 9 | 4.48 | .283 | 1.15 | 7.7 | 2.6 | 5.8 | 187.0 | 161 | 104 | 93 | 41 | 54 | 121 | 14 | 0 | 0 | 2 | 13 | 6 | 2 | 5.52 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 98 | 81 | 0 | 2 | 1 | 1.72 | .254 | 1.01 | 4.8 | 4.4 | 10.8 | 99.2 | 53 | 20 | 19 | 9 | 48 | 119 | 0 | 11 | 4 | 0 | 0 | 1 | 8 | 3.26 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 83 | 53 | 0 | 2 | 4 | 2.84 | .275 | 1.14 | 7.5 | 2.9 | 10.6 | 66.2 | 55 | 21 | 21 | 5 | 21 | 78 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 2.58 |
| RP | Chavez, J.Chavez, Jesse >> | 35 | 2018 | R | 58 | 36 | 0 | 5 | 5 | 2.20 | .258 | 1.02 | 8.3 | 0.9 | 7.9 | 49.0 | 45 | 20 | 12 | 5 | 5 | 43 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.94 |
| RP | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 62 | 24 | 0 | 5 | 2 | 2.67 | .236 | 0.93 | 5.3 | 3.0 | 8.3 | 27.0 | 16 | 8 | 8 | 3 | 9 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 3.59 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 61 | 16 | 0 | 2 | 0 | 2.00 | .182 | 0.61 | 2.5 | 3.0 | 7.5 | 18.0 | 5 | 4 | 4 | 1 | 6 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.22 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 45 | 23 | 0 | 4 | 0 | 1.99 | .275 | 1.07 | 7.0 | 2.9 | 9.6 | 31.2 | 24 | 10 | 7 | 3 | 10 | 33 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.29 |
| SP | Reulbach, E.Reulbach, Ed >> | 23 | 1905 | R | 59 | 11 | 0 | 0 | 3 | 3.57 | .306 | 1.30 | 8.7 | 3.1 | 6.3 | 53.0 | 51 | 24 | 21 | 3 | 18 | 37 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 3.42 |