| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 26 | 26 | 9 | 12 | 4.19 | .302 | 1.29 | 8.9 | 2.8 | 8.0 | 186.2 | 183 | 90 | 87 | 22 | 57 | 165 | 7 | 0 | 0 | 2 | 13 | 2 | 6 | 3.72 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 85 | 25 | 25 | 5 | 12 | 5.28 | .339 | 1.53 | 10.5 | 3.3 | 5.3 | 121.0 | 141 | 73 | 71 | 18 | 44 | 71 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 4.88 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 25 | 25 | 9 | 8 | 4.69 | .312 | 1.33 | 8.9 | 3.1 | 4.6 | 161.1 | 159 | 86 | 84 | 24 | 56 | 83 | 5 | 0 | 0 | 1 | 12 | 4 | 0 | 5.02 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 25 | 25 | 8 | 10 | 6.28 | .337 | 1.49 | 10.0 | 3.4 | 4.8 | 144.2 | 160 | 107 | 101 | 25 | 55 | 76 | 3 | 0 | 0 | 0 | 8 | 6 | 2 | 5.47 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 25 | 25 | 10 | 11 | 4.73 | .334 | 1.50 | 9.2 | 4.4 | 3.7 | 148.1 | 151 | 89 | 78 | 22 | 72 | 61 | 0 | 0 | 0 | 0 | 13 | 0 | 3 | 5.57 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 62 | 0 | 7 | 3 | 2.23 | .247 | 0.98 | 5.9 | 3.0 | 8.5 | 109.0 | 71 | 32 | 27 | 5 | 36 | 103 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 2.70 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 56 | 0 | 5 | 2 | 3.57 | .300 | 1.29 | 8.7 | 3.0 | 7.7 | 70.2 | 68 | 30 | 28 | 11 | 23 | 60 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 4.31 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 45 | 0 | 1 | 2 | 3.21 | .295 | 1.20 | 7.8 | 3.1 | 7.1 | 53.1 | 46 | 19 | 19 | 4 | 18 | 42 | 0 | 4 | 1 | 0 | 0 | 3 | 1 | 3.58 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 33 | 0 | 2 | 1 | 2.75 | .280 | 1.17 | 5.9 | 4.7 | 8.7 | 52.1 | 34 | 16 | 16 | 3 | 27 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 14 | 0 | 2 | 1 | 4.38 | .275 | 1.14 | 7.5 | 3.0 | 5.3 | 24.2 | 20 | 12 | 12 | 4 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.00 |