| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 7 | 6 | 2.41 | .257 | 1.03 | 7.0 | 2.3 | 9.1 | 141.2 | 110 | 45 | 38 | 10 | 36 | 142 | 1 | 0 | 0 | 1 | 16 | 1 | 0 | 2.70 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 21 | 21 | 9 | 5 | 3.33 | .300 | 1.26 | 8.0 | 3.4 | 5.7 | 148.2 | 132 | 62 | 55 | 13 | 56 | 93 | 4 | 0 | 0 | 1 | 14 | 3 | 2 | 4.08 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 9 | 9 | 3 | 3 | 4.56 | .304 | 1.29 | 7.3 | 4.4 | 6.8 | 53.1 | 43 | 27 | 27 | 8 | 26 | 40 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 4.98 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 52 | 0 | 3 | 1 | 3.23 | .259 | 1.00 | 6.5 | 2.5 | 9.2 | 39.0 | 28 | 17 | 14 | 6 | 11 | 40 | 0 | 7 | 0 | 0 | 0 | 2 | 2 | 3.95 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 56 | 0 | 3 | 4 | 3.02 | .265 | 1.08 | 7.5 | 2.4 | 6.8 | 53.2 | 44 | 19 | 18 | 5 | 14 | 40 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 3.51 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 38 | 0 | 4 | 1 | 3.76 | .307 | 1.28 | 8.1 | 3.6 | 9.2 | 38.1 | 34 | 19 | 16 | 4 | 15 | 39 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 3.66 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 25 | 0 | 1 | 3 | 5.00 | .314 | 1.33 | 8.0 | 4.0 | 9.0 | 27.0 | 24 | 17 | 15 | 2 | 12 | 27 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.41 |
| CL | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 17 | 0 | 0 | 3 | 5.79 | .455 | 2.50 | 14.8 | 7.7 | 3.9 | 14.0 | 23 | 10 | 9 | 0 | 12 | 6 | 0 | 10 | 3 | 0 | 0 | 0 | 0 | 4.71 |