| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 23 | 23 | 8 | 8 | 4.70 | .318 | 1.38 | 8.7 | 3.8 | 4.1 | 147.1 | 142 | 82 | 77 | 18 | 62 | 67 | 1 | 0 | 0 | 0 | 13 | 2 | 0 | 4.99 |
| SP | Tiant, L.Tiant, Luis † # >> | 28 | 1968 | R | 97 | 22 | 22 | 10 | 5 | 3.25 | .284 | 1.18 | 8.0 | 2.7 | 7.5 | 166.1 | 147 | 63 | 60 | 11 | 49 | 138 | 4 | 0 | 0 | 1 | 14 | 2 | 2 | 3.12 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 21 | 21 | 12 | 8 | 4.10 | .299 | 1.27 | 9.3 | 2.2 | 5.4 | 158.0 | 163 | 76 | 72 | 23 | 38 | 95 | 5 | 0 | 0 | 0 | 10 | 1 | 2 | 4.43 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 21 | 21 | 4 | 8 | 5.76 | .330 | 1.45 | 9.5 | 3.6 | 3.9 | 131.1 | 138 | 87 | 84 | 23 | 52 | 57 | 1 | 0 | 0 | 0 | 7 | 4 | 1 | 5.69 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 20 | 20 | 6 | 8 | 4.72 | .338 | 1.50 | 9.2 | 4.3 | 8.8 | 118.1 | 121 | 64 | 62 | 13 | 56 | 116 | 1 | 0 | 0 | 0 | 12 | 4 | 1 | 3.99 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 49 | 0 | 8 | 4 | 3.12 | .276 | 1.09 | 6.6 | 3.3 | 7.1 | 57.2 | 42 | 20 | 20 | 4 | 21 | 45 | 0 | 20 | 2 | 0 | 0 | 3 | 1 | 3.60 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 54 | 0 | 3 | 3 | 2.93 | .294 | 1.25 | 8.2 | 3.1 | 9.5 | 58.1 | 53 | 21 | 19 | 9 | 20 | 61 | 0 | 5 | 3 | 0 | 0 | 0 | 2 | 3.95 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 23 | 0 | 2 | 1 | 4.73 | .298 | 1.28 | 9.7 | 2.1 | 10.4 | 26.2 | 28 | 15 | 14 | 5 | 6 | 30 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.88 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 24 | 0 | 1 | 1 | 3.51 | .280 | 1.17 | 7.6 | 3.2 | 10.1 | 25.2 | 21 | 10 | 10 | 3 | 9 | 28 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.40 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 12 | 0 | 0 | 0 | 5.40 | .352 | 1.63 | 9.4 | 5.5 | 8.1 | 41.2 | 43 | 25 | 25 | 5 | 25 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.61 |