| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 36 | 36 | 19 | 9 | 3.32 | .270 | 1.07 | 7.3 | 2.3 | 9.4 | 260.0 | 212 | 100 | 96 | 27 | 67 | 271 | 4 | 0 | 0 | 1 | 25 | 9 | 0 | 3.14 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 32 | 32 | 13 | 12 | 4.66 | .320 | 1.38 | 9.7 | 2.7 | 4.4 | 220.0 | 238 | 121 | 114 | 30 | 65 | 107 | 8 | 0 | 0 | 2 | 14 | 7 | 7 | 4.78 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 75 | 0 | 4 | 4 | 1.91 | .247 | 0.98 | 5.6 | 3.3 | 8.8 | 94.1 | 58 | 22 | 20 | 3 | 34 | 92 | 0 | 39 | 5 | 0 | 0 | 1 | 2 | 2.57 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 38 | 0 | 2 | 1 | 3.50 | .294 | 1.21 | 7.8 | 3.1 | 8.2 | 46.1 | 40 | 19 | 18 | 3 | 16 | 42 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.20 |