| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 33 | 33 | 11 | 17 | 5.07 | .318 | 1.37 | 9.8 | 2.6 | 4.5 | 232.2 | 252 | 132 | 131 | 26 | 66 | 115 | 9 | 0 | 0 | 2 | 12 | 7 | 5 | 4.41 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 33 | 33 | 6 | 14 | 7.37 | .390 | 1.90 | 13.4 | 3.7 | 4.3 | 145.1 | 216 | 123 | 119 | 24 | 60 | 69 | 0 | 0 | 0 | 0 | 4 | 3 | 6 | 5.50 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 9 | 16 | 5.71 | .342 | 1.53 | 10.3 | 3.5 | 3.8 | 200.1 | 229 | 137 | 127 | 25 | 78 | 84 | 2 | 0 | 0 | 1 | 11 | 5 | 4 | 5.03 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 66 | 32 | 31 | 9 | 18 | 6.08 | .348 | 1.57 | 10.3 | 3.8 | 5.5 | 191.0 | 219 | 131 | 129 | 25 | 81 | 116 | 5 | 0 | 0 | 1 | 10 | 6 | 6 | 4.85 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 99 | 0 | 11 | 3 | 2.82 | .276 | 1.13 | 7.0 | 3.2 | 9.2 | 137.1 | 106 | 45 | 43 | 5 | 49 | 140 | 0 | 7 | 1 | 0 | 0 | 2 | 6 | 2.55 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 87 | 0 | 7 | 4 | 6.09 | .340 | 1.52 | 9.6 | 4.2 | 9.0 | 106.1 | 113 | 78 | 72 | 18 | 49 | 106 | 0 | 8 | 2 | 0 | 0 | 2 | 4 | 4.65 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 69 | 0 | 3 | 2 | 3.02 | .309 | 1.31 | 8.1 | 3.8 | 8.0 | 86.1 | 77 | 32 | 29 | 9 | 36 | 76 | 0 | 8 | 1 | 0 | 0 | 3 | 1 | 3.95 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 62 | 0 | 4 | 3 | 5.47 | .325 | 1.43 | 9.0 | 3.9 | 8.6 | 74.0 | 74 | 53 | 45 | 10 | 32 | 71 | 0 | 6 | 4 | 0 | 0 | 1 | 2 | 4.18 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 50 | 0 | 0 | 0 | 5.77 | .352 | 1.61 | 10.3 | 4.4 | 4.6 | 57.2 | 65 | 39 | 37 | 8 | 28 | 29 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.33 |