| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 20 | 20 | 11 | 4 | 2.39 | .268 | 1.08 | 7.1 | 2.6 | 8.0 | 143.0 | 113 | 41 | 38 | 13 | 41 | 127 | 5 | 0 | 0 | 1 | 16 | 3 | 6 | 3.33 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 86 | 21 | 21 | 10 | 5 | 5.43 | .331 | 1.45 | 9.9 | 3.1 | 3.5 | 116.0 | 128 | 75 | 70 | 17 | 40 | 45 | 1 | 0 | 0 | 0 | 9 | 4 | 2 | 5.27 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 21 | 21 | 11 | 2 | 3.76 | .288 | 1.18 | 8.8 | 1.9 | 4.3 | 129.1 | 126 | 56 | 54 | 16 | 27 | 61 | 1 | 0 | 0 | 1 | 11 | 4 | 2 | 4.39 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 20 | 20 | 8 | 10 | 3.88 | .280 | 1.15 | 7.3 | 3.1 | 7.2 | 155.1 | 125 | 71 | 67 | 12 | 53 | 124 | 9 | 0 | 0 | 3 | 10 | 3 | 2 | 3.49 |
| RP | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 55 | 0 | 1 | 2 | 1.86 | .224 | 0.85 | 3.5 | 4.3 | 10.8 | 72.2 | 28 | 16 | 15 | 3 | 34 | 86 | 0 | 14 | 1 | 0 | 0 | 1 | 5 | 2.61 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 33 | 0 | 2 | 3 | 3.71 | .297 | 1.26 | 9.3 | 2.1 | 8.5 | 34.0 | 35 | 17 | 14 | 3 | 8 | 32 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 2.97 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 28 | 0 | 3 | 1 | 4.56 | .313 | 1.29 | 9.0 | 2.9 | 12.2 | 25.2 | 25 | 13 | 13 | 5 | 8 | 34 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 4.08 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 24 | 0 | 1 | 2 | 3.56 | .266 | 1.09 | 6.9 | 3.0 | 9.3 | 30.1 | 23 | 12 | 12 | 6 | 10 | 31 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.53 |