| SP | Verlander, J.Verlander, Justin † # >> | 36 | 2019 | R | 99 | 21 | 21 | 10 | 9 | 2.80 | .265 | 1.07 | 7.3 | 2.3 | 9.5 | 141.1 | 115 | 51 | 44 | 9 | 36 | 149 | 2 | 0 | 0 | 0 | 16 | 2 | 3 | 2.52 |
| SP | Kluber, C.Kluber, Corey † >> | 31 | 2017 | R | 90 | 21 | 21 | 13 | 5 | 3.42 | .272 | 1.09 | 7.8 | 2.0 | 8.6 | 152.2 | 132 | 61 | 58 | 21 | 34 | 146 | 3 | 0 | 0 | 3 | 12 | 5 | 1 | 3.64 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 20 | 20 | 4 | 9 | 5.21 | .331 | 1.46 | 9.5 | 3.8 | 7.7 | 115.2 | 121 | 70 | 67 | 18 | 48 | 99 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 4.64 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 20 | 20 | 5 | 6 | 3.73 | .308 | 1.31 | 7.9 | 3.9 | 7.1 | 130.1 | 114 | 60 | 54 | 12 | 57 | 103 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 4.00 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 38 | 0 | 1 | 2 | 2.62 | .270 | 1.08 | 7.9 | 1.9 | 8.5 | 34.1 | 30 | 13 | 10 | 3 | 7 | 32 | 0 | 30 | 3 | 0 | 0 | 1 | 3 | 2.97 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 42 | 0 | 3 | 2 | 1.59 | .250 | 0.96 | 4.9 | 3.7 | 9.7 | 51.0 | 28 | 9 | 9 | 1 | 21 | 55 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 2.45 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 24 | 0 | 3 | 1 | 5.88 | .386 | 1.81 | 8.7 | 7.6 | 10.7 | 26.0 | 25 | 17 | 17 | 4 | 22 | 31 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.38 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 17 | 0 | 1 | 1 | 7.27 | .373 | 1.79 | 10.1 | 6.4 | 9.0 | 17.1 | 19 | 14 | 14 | 4 | 12 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.18 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 21 | 0 | 0 | 0 | 4.63 | .327 | 1.41 | 8.6 | 4.3 | 11.7 | 23.1 | 22 | 12 | 12 | 3 | 11 | 30 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.65 |