| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 97 | 28 | 28 | 14 | 9 | 3.49 | .286 | 1.18 | 7.0 | 3.6 | 9.8 | 193.1 | 151 | 75 | 75 | 24 | 77 | 211 | 2 | 0 | 0 | 0 | 17 | 4 | 4 | 3.69 |
| SP | Flaherty, J.Flaherty, Jack # >> | 23 | 2019 | R | 83 | 27 | 27 | 8 | 10 | 4.14 | .302 | 1.26 | 8.8 | 2.6 | 9.5 | 167.1 | 163 | 80 | 77 | 16 | 48 | 176 | 0 | 0 | 0 | 0 | 15 | 6 | 7 | 3.11 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 27 | 27 | 7 | 4 | 4.47 | .336 | 1.49 | 9.1 | 4.3 | 8.6 | 157.0 | 159 | 78 | 78 | 20 | 75 | 150 | 0 | 0 | 0 | 0 | 14 | 4 | 2 | 4.25 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 76 | 0 | 2 | 4 | 4.09 | .309 | 1.30 | 8.6 | 3.1 | 11.0 | 99.0 | 95 | 48 | 45 | 14 | 34 | 121 | 0 | 10 | 6 | 0 | 0 | 4 | 4 | 3.55 |
| RP | Soriano, R.Soriano, Rafael † >> | 24 | 2003 | R | 84 | 70 | 0 | 12 | 9 | 3.21 | .302 | 1.26 | 8.3 | 3.1 | 10.0 | 92.2 | 85 | 33 | 33 | 9 | 32 | 102 | 0 | 7 | 7 | 0 | 0 | 3 | 0 | 3.20 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 48 | 0 | 4 | 2 | 2.38 | .303 | 1.31 | 6.8 | 5.1 | 10.4 | 56.2 | 42 | 15 | 15 | 4 | 32 | 65 | 0 | 7 | 3 | 0 | 0 | 0 | 1 | 3.32 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 59 | 13 | 0 | 2 | 1 | 8.35 | .396 | 1.96 | 11.5 | 6.5 | 7.0 | 18.1 | 23 | 17 | 17 | 2 | 13 | 14 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 5.06 |