| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 99 | 35 | 35 | 16 | 13 | 3.55 | .291 | 1.21 | 7.8 | 3.2 | 9.4 | 238.1 | 205 | 102 | 94 | 28 | 84 | 249 | 2 | 0 | 0 | 0 | 22 | 4 | 4 | 3.55 |
| SP | Bauer, T.Bauer, Trevor # >> | 27 | 2018 | R | 60 | 33 | 33 | 12 | 7 | 3.50 | .264 | 1.06 | 6.8 | 2.8 | 10.2 | 182.2 | 137 | 71 | 71 | 22 | 57 | 207 | 1 | 0 | 0 | 1 | 12 | 3 | 5 | 3.29 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 34 | 34 | 14 | 12 | 3.46 | .298 | 1.24 | 8.2 | 2.9 | 8.6 | 205.1 | 187 | 86 | 79 | 17 | 67 | 196 | 0 | 0 | 0 | 0 | 21 | 8 | 12 | 3.26 |
| SP | Wainwright, A.Wainwright, Adam >> | 33 | 2014 | R | 56 | 32 | 32 | 18 | 6 | 3.51 | .287 | 1.18 | 8.4 | 2.3 | 7.0 | 184.2 | 171 | 76 | 72 | 27 | 46 | 144 | 0 | 0 | 0 | 0 | 18 | 6 | 1 | 4.19 |
| CL | Leclerc, J.Leclerc, Jose >> | 24 | 2018 | R | 87 | 74 | 0 | 2 | 1 | 2.64 | .264 | 1.06 | 5.1 | 4.6 | 10.9 | 71.2 | 40 | 21 | 21 | 3 | 36 | 86 | 0 | 5 | 6 | 0 | 0 | 1 | 1 | 2.69 |
| RP | Green, C.Green, Chad † >> | 26 | 2017 | R | 97 | 70 | 0 | 5 | 5 | 3.94 | .298 | 1.26 | 8.2 | 3.2 | 10.3 | 75.1 | 68 | 33 | 33 | 7 | 27 | 86 | 0 | 45 | 6 | 0 | 0 | 1 | 1 | 3.04 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 73 | 81 | 0 | 9 | 1 | 2.11 | .228 | 0.86 | 4.9 | 3.0 | 7.6 | 76.2 | 41 | 18 | 18 | 6 | 25 | 64 | 0 | 2 | 2 | 0 | 0 | 2 | 4 | 3.41 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 86 | 84 | 0 | 7 | 0 | 2.73 | .280 | 1.11 | 6.1 | 3.8 | 10.4 | 82.1 | 56 | 25 | 25 | 7 | 35 | 95 | 0 | 2 | 2 | 0 | 0 | 5 | 3 | 3.26 |
| RP | Osuna, R.Osuna, Roberto >> | 22 | 2017 | R | 60 | 66 | 0 | 3 | 3 | 2.92 | .305 | 1.22 | 8.1 | 3.0 | 10.2 | 61.2 | 55 | 21 | 20 | 6 | 20 | 69 | 0 | 4 | 1 | 0 | 0 | 6 | 5 | 3.30 |
| SP | Richards, G.Richards, Garrett >> | 26 | 2014 | R | 72 | 32 | 16 | 14 | 4 | 3.07 | .303 | 1.27 | 7.2 | 4.2 | 7.4 | 126.0 | 101 | 47 | 43 | 8 | 59 | 103 | 0 | 0 | 0 | 0 | 7 | 4 | 16 | 3.69 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 83 | 30 | 16 | 5 | 6 | 4.83 | .312 | 1.34 | 8.8 | 3.3 | 6.5 | 128.2 | 125 | 74 | 69 | 17 | 47 | 93 | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 4.45 |