| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 17 | 17 | 7 | 4 | 3.16 | .283 | 1.19 | 7.7 | 3.0 | 6.2 | 122.1 | 104 | 45 | 43 | 9 | 41 | 84 | 6 | 0 | 0 | 0 | 13 | 0 | 2 | 3.59 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 18 | 18 | 7 | 7 | 4.60 | .291 | 1.21 | 8.4 | 2.6 | 6.2 | 105.2 | 98 | 56 | 54 | 13 | 30 | 72 | 5 | 0 | 0 | 1 | 7 | 2 | 5 | 4.15 |
| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 81 | 17 | 17 | 10 | 1 | 2.77 | .262 | 1.07 | 5.6 | 4.0 | 8.2 | 104.0 | 65 | 33 | 32 | 4 | 46 | 95 | 0 | 0 | 0 | 0 | 11 | 0 | 5 | 3.00 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 17 | 17 | 8 | 2 | 3.46 | .268 | 1.10 | 7.0 | 2.9 | 6.4 | 109.1 | 85 | 44 | 42 | 8 | 35 | 77 | 1 | 0 | 0 | 0 | 11 | 0 | 1 | 3.50 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 48 | 0 | 2 | 2 | 3.40 | .270 | 1.04 | 5.4 | 4.0 | 9.2 | 45.0 | 27 | 18 | 17 | 4 | 20 | 46 | 0 | 4 | 5 | 0 | 0 | 3 | 0 | 3.64 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 19 | 0 | 1 | 1 | 6.06 | .310 | 1.35 | 6.8 | 5.6 | 12.4 | 16.1 | 12 | 11 | 11 | 4 | 10 | 22 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 5.38 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 14 | 0 | 0 | 2 | 9.49 | .362 | 1.70 | 12.0 | 3.8 | 12.0 | 12.1 | 16 | 13 | 13 | 2 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.75 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 34 | 0 | 2 | 2 | 2.44 | .265 | 1.08 | 6.5 | 3.3 | 8.0 | 44.1 | 32 | 13 | 12 | 2 | 16 | 39 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 2.91 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 15 | 2 | 4 | 1 | 2.88 | .294 | 1.20 | 7.3 | 3.6 | 7.5 | 65.2 | 53 | 23 | 21 | 3 | 26 | 54 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 3.28 |