| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 97 | 29 | 29 | 9 | 11 | 4.21 | .302 | 1.27 | 8.9 | 2.6 | 8.8 | 184.0 | 181 | 94 | 86 | 20 | 53 | 180 | 6 | 0 | 0 | 2 | 15 | 5 | 7 | 3.40 |
| SP | Alexander, P.Alexander, Pete $ >> | 28 | 1915 | R | 88 | 28 | 28 | 13 | 8 | 3.76 | .290 | 1.20 | 8.1 | 2.8 | 5.2 | 182.0 | 163 | 81 | 76 | 23 | 56 | 105 | 7 | 0 | 0 | 1 | 17 | 4 | 3 | 4.48 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 81 | 27 | 27 | 11 | 7 | 3.56 | .299 | 1.26 | 7.2 | 4.2 | 8.6 | 156.2 | 124 | 68 | 62 | 17 | 73 | 149 | 0 | 0 | 0 | 0 | 16 | 3 | 8 | 3.97 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 27 | 27 | 10 | 10 | 4.61 | .323 | 1.40 | 9.3 | 3.4 | 5.3 | 140.2 | 144 | 80 | 72 | 16 | 53 | 82 | 1 | 0 | 0 | 1 | 12 | 4 | 3 | 4.54 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 71 | 27 | 26 | 8 | 7 | 6.57 | .353 | 1.60 | 9.9 | 4.5 | 7.9 | 124.2 | 137 | 95 | 91 | 20 | 62 | 109 | 0 | 0 | 0 | 0 | 7 | 5 | 3 | 4.96 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 86 | 76 | 0 | 5 | 3 | 3.60 | .296 | 1.25 | 8.7 | 2.6 | 8.0 | 95.0 | 92 | 40 | 38 | 13 | 27 | 84 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 3.89 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 62 | 0 | 6 | 1 | 2.96 | .305 | 1.26 | 5.5 | 5.8 | 7.1 | 70.0 | 43 | 24 | 23 | 5 | 45 | 55 | 0 | 6 | 1 | 0 | 0 | 4 | 0 | 4.46 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 45 | 0 | 5 | 1 | 3.75 | .287 | 1.19 | 6.0 | 4.7 | 9.2 | 48.0 | 32 | 22 | 20 | 9 | 25 | 49 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 5.02 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 28 | 0 | 4 | 1 | 5.91 | .327 | 1.40 | 10.3 | 2.3 | 9.5 | 35.0 | 40 | 23 | 23 | 8 | 9 | 37 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.80 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 59 | 0 | 6 | 4 | 2.05 | .233 | 0.88 | 6.1 | 1.9 | 8.2 | 87.2 | 59 | 23 | 20 | 4 | 18 | 79 | 0 | 14 | 5 | 0 | 0 | 3 | 1 | 2.51 |