| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 28 | 28 | 10 | 11 | 3.84 | .283 | 1.16 | 8.3 | 2.2 | 9.5 | 187.1 | 172 | 81 | 80 | 23 | 45 | 198 | 3 | 0 | 0 | 2 | 16 | 5 | 0 | 3.28 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 73 | 27 | 27 | 11 | 8 | 3.82 | .274 | 1.12 | 7.3 | 2.8 | 5.5 | 193.0 | 157 | 87 | 82 | 19 | 59 | 119 | 2 | 0 | 0 | 0 | 19 | 3 | 1 | 4.01 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 66 | 27 | 27 | 6 | 11 | 4.66 | .330 | 1.46 | 9.1 | 4.1 | 6.4 | 181.2 | 184 | 98 | 94 | 21 | 82 | 128 | 5 | 0 | 0 | 2 | 13 | 3 | 1 | 4.50 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 64 | 27 | 27 | 9 | 13 | 4.30 | .323 | 1.40 | 9.5 | 3.2 | 4.6 | 211.1 | 222 | 109 | 101 | 25 | 74 | 108 | 12 | 0 | 0 | 1 | 10 | 7 | 8 | 4.67 |
| SP | Caldwell, R.Caldwell, Ray # >> | 26 | 1914 | R | 64 | 26 | 26 | 7 | 8 | 5.75 | .358 | 1.64 | 11.2 | 3.6 | 4.4 | 153.1 | 190 | 106 | 98 | 15 | 62 | 74 | 0 | 0 | 0 | 0 | 9 | 4 | 2 | 4.60 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 67 | 0 | 5 | 5 | 3.41 | .291 | 1.23 | 7.2 | 3.8 | 6.8 | 87.0 | 70 | 34 | 33 | 9 | 37 | 66 | 0 | 2 | 7 | 0 | 0 | 0 | 2 | 4.10 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 57 | 0 | 6 | 7 | 4.33 | .292 | 1.24 | 7.5 | 3.8 | 9.4 | 72.2 | 60 | 35 | 35 | 9 | 30 | 75 | 0 | 4 | 4 | 0 | 0 | 0 | 2 | 3.79 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 33 | 0 | 3 | 3 | 3.33 | .274 | 1.13 | 6.9 | 3.4 | 9.5 | 51.1 | 39 | 19 | 19 | 5 | 19 | 54 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 3.27 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 57 | 1 | 1 | 0 | 0 | 5.06 | .385 | 1.88 | 10.8 | 7.2 | 5.4 | 5.1 | 6 | 3 | 3 | 2 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.40 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 1 | 0 | 0 | 0 | 3.38 | .429 | 1.88 | 22.5 | 0.0 | 0.0 | 2.2 | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.50 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 17 | 0 | 1 | 3 | 6.83 | .394 | 1.95 | 13.0 | 5.0 | 6.0 | 27.2 | 39 | 22 | 21 | 6 | 15 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 6.22 |