| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 16 | 16 | 7 | 6 | 3.72 | .291 | 1.22 | 8.2 | 2.9 | 8.9 | 123.1 | 112 | 52 | 51 | 12 | 39 | 122 | 4 | 0 | 0 | 1 | 9 | 1 | 2 | 3.26 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 15 | 15 | 8 | 4 | 4.42 | .312 | 1.34 | 8.9 | 3.2 | 6.7 | 97.2 | 96 | 48 | 48 | 13 | 35 | 72 | 2 | 0 | 0 | 1 | 8 | 2 | 3 | 4.40 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 15 | 15 | 7 | 5 | 4.12 | .315 | 1.38 | 8.7 | 3.8 | 4.6 | 113.2 | 109 | 54 | 52 | 5 | 48 | 58 | 6 | 0 | 0 | 3 | 7 | 0 | 4 | 3.82 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 68 | 15 | 15 | 3 | 9 | 5.76 | .360 | 1.69 | 10.9 | 4.4 | 7.8 | 90.2 | 109 | 63 | 58 | 13 | 44 | 78 | 0 | 0 | 0 | 0 | 7 | 0 | 2 | 4.61 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 16 | 0 | 2 | 1 | 3.74 | .253 | 1.02 | 6.9 | 2.6 | 7.7 | 21.2 | 16 | 9 | 9 | 2 | 6 | 18 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 12 | 0 | 0 | 2 | 2.35 | .179 | 0.65 | 4.8 | 1.2 | 9.0 | 15.1 | 8 | 4 | 4 | 2 | 2 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.13 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 7 | 0 | 0 | 2 | 9.45 | .474 | 2.70 | 13.5 | 13.5 | 12.0 | 6.2 | 9 | 7 | 7 | 1 | 9 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.00 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 6 | 0 | 0 | 0 | 3.52 | .343 | 1.43 | 11.6 | 2.6 | 6.4 | 7.2 | 9 | 3 | 3 | 1 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.71 |