| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 16 | 7 | 3.18 | .280 | 1.15 | 8.2 | 2.1 | 10.1 | 223.1 | 203 | 83 | 79 | 27 | 53 | 251 | 0 | 0 | 0 | 0 | 26 | 4 | 0 | 3.09 |
| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 92 | 33 | 33 | 16 | 8 | 3.64 | .302 | 1.29 | 8.4 | 3.2 | 7.3 | 237.2 | 222 | 101 | 96 | 27 | 84 | 191 | 3 | 0 | 0 | 1 | 18 | 3 | 6 | 3.97 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 93 | 32 | 32 | 18 | 10 | 3.62 | .285 | 1.18 | 7.8 | 2.8 | 5.1 | 253.2 | 220 | 102 | 102 | 25 | 80 | 144 | 20 | 0 | 0 | 3 | 17 | 4 | 6 | 4.14 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 77 | 31 | 31 | 13 | 12 | 4.18 | .299 | 1.25 | 9.3 | 2.0 | 4.7 | 245.1 | 252 | 118 | 114 | 25 | 55 | 128 | 14 | 0 | 0 | 1 | 14 | 7 | 5 | 4.04 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 78 | 0 | 9 | 1 | 2.03 | .231 | 0.88 | 5.8 | 2.1 | 7.4 | 110.2 | 71 | 26 | 25 | 8 | 26 | 90 | 0 | 9 | 3 | 0 | 0 | 3 | 1 | 3.10 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 66 | 0 | 6 | 9 | 3.94 | .290 | 1.21 | 9.5 | 1.5 | 8.7 | 80.0 | 84 | 38 | 35 | 10 | 13 | 77 | 0 | 12 | 1 | 0 | 0 | 1 | 0 | 3.23 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 44 | 0 | 4 | 7 | 4.50 | .314 | 1.38 | 9.2 | 3.2 | 7.2 | 40.0 | 41 | 21 | 20 | 11 | 14 | 32 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 6.03 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 19 | 0 | 3 | 0 | 2.70 | .294 | 1.25 | 6.3 | 5.0 | 9.5 | 20.0 | 14 | 6 | 6 | 3 | 11 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 16 | 0 | 0 | 0 | 2.38 | .236 | 0.88 | 7.4 | 0.8 | 9.4 | 22.2 | 18 | 6 | 6 | 4 | 2 | 23 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.68 |