| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 13 | 13 | 8 | 4 | 3.27 | .302 | 1.29 | 8.4 | 3.3 | 6.6 | 104.2 | 97 | 41 | 38 | 6 | 38 | 76 | 6 | 0 | 0 | 1 | 8 | 1 | 3 | 3.41 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 12 | 12 | 5 | 6 | 4.52 | .334 | 1.51 | 9.7 | 4.0 | 6.9 | 83.2 | 89 | 49 | 42 | 9 | 37 | 64 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 4.20 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 12 | 12 | 6 | 0 | 3.24 | .324 | 1.41 | 7.5 | 5.3 | 6.6 | 72.1 | 60 | 32 | 26 | 7 | 42 | 53 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 4.63 |
| SP | Liriano, F.Liriano, Francisco # >> | 23 | 2006 | L | 60 | 11 | 11 | 0 | 3 | 6.75 | .366 | 1.71 | 10.5 | 5.1 | 8.8 | 42.2 | 49 | 32 | 32 | 8 | 24 | 41 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 5.31 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 32 | 0 | 3 | 0 | 3.08 | .288 | 1.16 | 7.6 | 2.8 | 7.1 | 38.0 | 32 | 14 | 13 | 4 | 12 | 30 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 3.89 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 23 | 0 | 3 | 3 | 3.29 | .299 | 1.28 | 9.0 | 2.7 | 11.0 | 27.1 | 27 | 14 | 10 | 7 | 8 | 33 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.81 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 20 | 0 | 2 | 2 | 8.35 | .375 | 1.75 | 12.0 | 4.0 | 9.5 | 18.1 | 24 | 17 | 17 | 7 | 8 | 19 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 7.44 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 15 | 0 | 1 | 1 | 3.32 | .323 | 1.38 | 8.1 | 4.7 | 6.4 | 21.2 | 19 | 8 | 8 | 1 | 11 | 15 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.90 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 59 | 7 | 1 | 0 | 2 | 6.46 | .395 | 1.96 | 13.8 | 4.2 | 2.4 | 15.1 | 23 | 16 | 11 | 2 | 7 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.60 |